Document type
Book chapters
Title
Airway epithelial cells for Cystic Fibrosis studies
Participants in the publication
Amaral MD (Author)
Dep. Química e Bioquímica
BioISI
Railean V (Author)
BioISI
Rodrigues CS (Author)
BioISI
Pankonien I (Author)
Dep. Química e Bioquímica
BioISI
Summary
The different respiratory cell types and their characteristics, and molecular markers are summarized\\nhere. Basal cells are adult stem cells underlying the basal lamina of airways and their principal role is to maintain and repair the tissue. Basal cells represent 6 to 30% of airway epithelium, depending on the location in the respiratory tract. They are responsible for attaching the columnar epithelium to the basement membrane zone as well as interacting with\\nimmune cells and neurons. Basal cells are also important to promote regeneration after injury, due to their ability to self-renew and to differentiate into specialized cells such as ciliated and secretory cells. These specialized cells go on to form the pseudostratified airway epithelium. Basal cells can be identified by several cellular markers, including tumor protein 63 (TP63), cytoskeletal protein keratin 5 (KRT5) and nerve growth factor receptor (NGFR).\\nIn this review, we describe the multiple airway epithelial cells that can be used for Cystic Fibrosis studies, their advantages and disadvantages, depending on the aim of the study.
Editor(s)
Carsten Schwarz; Isabelle Sermet-Gaudelus;Dorota Sands;Daniel Peckham
Date of Publication
2023-04-30
Institution
EUROPEAN CYSTIC FIBROSIS SOCIETY
Where published
Inflammation and infection in cystic fibrosis
Publication Identifiers
Publisher
ECFS
Number of pages
15
Starting page
29
Last page
44
Rankings
FCUL CC Recognition