Tipo
Capítulo em Livro
Título
Airway epithelial cells for Cystic Fibrosis studies
Participantes na publicação
Amaral MD (Author)
Dep. Química e Bioquímica
BioISI
Railean V (Author)
BioISI
Rodrigues CS (Author)
BioISI
Pankonien I (Author)
Dep. Química e Bioquímica
BioISI
Resumo
The different respiratory cell types and their characteristics, and molecular markers are summarized\\nhere. Basal cells are adult stem cells underlying the basal lamina of airways and their principal role is to maintain and repair the tissue. Basal cells represent 6 to 30% of airway epithelium, depending on the location in the respiratory tract. They are responsible for attaching the columnar epithelium to the basement membrane zone as well as interacting with\\nimmune cells and neurons. Basal cells are also important to promote regeneration after injury, due to their ability to self-renew and to differentiate into specialized cells such as ciliated and secretory cells. These specialized cells go on to form the pseudostratified airway epithelium. Basal cells can be identified by several cellular markers, including tumor protein 63 (TP63), cytoskeletal protein keratin 5 (KRT5) and nerve growth factor receptor (NGFR).\\nIn this review, we describe the multiple airway epithelial cells that can be used for Cystic Fibrosis studies, their advantages and disadvantages, depending on the aim of the study.
Editor
Carsten Schwarz; Isabelle Sermet-Gaudelus;Dorota Sands;Daniel Peckham
Data de Publicação
2023-04-30
Instituição
EUROPEAN CYSTIC FIBROSIS SOCIETY
Suporte
Inflammation and infection in cystic fibrosis
Identificadores da Publicação
Editora
ECFS
Número de Páginas
15
Página Inicial
29
Página Final
44
Identificadores de Qualidade
FCUL CC Recognition