BIBLIOS

Document type
Journal articles

Document subtype
Full paper

Title
Insights into the thermochemistry of paracetamol in ternary mixtures of eutectic solvents

Participants in the publication
Andreia Lopes (Author)
Nélson Nunes (Author)
Ruben Elvas Leitão (Author)
Filomena Martins (Author)
Dep. Química e Bioquímica
CQE

Summary
Solution enthalpies of paracetamol, ΔsolH, in choline chloride–ethylene glycol–water mixtures were evaluated at 298.15 K. Solvatochromic UV–vis shifts of five different probes (4-nitroaniline, 4-nitroanisole, 4-nitrophenol, N,N-dimethyl-4-nitroaniline and 2,6-diphenyl-4-(2,4,6-triphenylpyridinium-1-yl)phenolate) were also assessed for the same mixtures at the same temperature in order to compute the corresponding Kamlet–Taft parameters, α, β, and π*. Quantitative structure–property relationships (QSPR) between ΔsolH and the solvatochromic parameters were established to investigate the solution processes under consideration. Due to the small variability in the solvent parameters, a further set of eight pure solvents were considered. The behavior of paracetamol in eutectic mixtures is shown to be not significantly different from its behaviour in the pure solvents. The solvents’ basicity measured by β, is the most relevant factor modeling the solution process of this solute in the total set of solvents.


Institution
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Where published
Journal of Thermal Analysis and Calorimetry

Publication Identifiers
ISSN - 1388-6150

Publisher
Springer Science and Business Media LLC



Document Identifiers
DOI - https://doi.org/10.1007/s10973-024-13383-2
URL - https://doi.org/10.1007/s10973-024-13383-2

Rankings
Web Of Science Q2 (2023) - 3.0 - Chemistry, Analytical
Web Of Science Q2 (2023) - 3.0 - Thermodynamics

Keywords
Ternary mixture · Choline chloride · Ethylene glycol · Water · Kamlet–Taft parameters · Solution enthalpies