BIBLIOS

Tipo
Artigos em Revista

Tipo de Documento
Artigo Completo

Título
Insights into the thermochemistry of paracetamol in ternary mixtures of eutectic solvents

Participantes na publicação
Andreia Lopes (Author)
Nélson Nunes (Author)
Ruben Elvas Leitão (Author)
Filomena Martins (Author)
Dep. Química e Bioquímica
CQE

Resumo
Solution enthalpies of paracetamol, ΔsolH, in choline chloride–ethylene glycol–water mixtures were evaluated at 298.15 K. Solvatochromic UV–vis shifts of five different probes (4-nitroaniline, 4-nitroanisole, 4-nitrophenol, N,N-dimethyl-4-nitroaniline and 2,6-diphenyl-4-(2,4,6-triphenylpyridinium-1-yl)phenolate) were also assessed for the same mixtures at the same temperature in order to compute the corresponding Kamlet–Taft parameters, α, β, and π*. Quantitative structure–property relationships (QSPR) between ΔsolH and the solvatochromic parameters were established to investigate the solution processes under consideration. Due to the small variability in the solvent parameters, a further set of eight pure solvents were considered. The behavior of paracetamol in eutectic mixtures is shown to be not significantly different from its behaviour in the pure solvents. The solvents’ basicity measured by β, is the most relevant factor modeling the solution process of this solute in the total set of solvents.


Instituição
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Suporte
Journal of Thermal Analysis and Calorimetry

Identificadores da Publicação
ISSN - 1388-6150

Editora
Springer Science and Business Media LLC



Identificadores do Documento
DOI - https://doi.org/10.1007/s10973-024-13383-2
URL - https://doi.org/10.1007/s10973-024-13383-2

Identificadores de Qualidade
Web Of Science Q2 (2023) - 3.0 - Chemistry, Analytical
Web Of Science Q2 (2023) - 3.0 - Thermodynamics

Keywords
Ternary mixture · Choline chloride · Ethylene glycol · Water · Kamlet–Taft parameters · Solution enthalpies