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Detalhes Referência

Tipo
Artigos em Revista

Tipo de Documento
Artigo Completo

Título
CyFi-MAP: an interactive pathway-based resource for cystic fibrosis

Participantes na publicação
Catarina Pereira (Author)
Alexander Mazein (Author)
Carlos M. Farinha (Author)
Dep. Química e Bioquímica
 BIOFIG
 BioISI
 Michael A. Gray (Author)
Karl Kunzelmann (Author)
Marek Ostaszewski (Author)
Irina Balaur (Author)
Margarida D. Amaral (Author)
Dep. Química e Bioquímica
 BIOFIG
 BioISI
 Andre O. Falcao (Author)
Dep. Informática
 LASIGE
Resumo
Cystic fibrosis (CF) is a life-threatening autosomal recessive disease caused by more than 2100 mutations in the CF transmembrane conductance regulator (CFTR) gene, generating variability in disease severity among individuals with CF sharing the same CFTR genotype. Systems biology can assist in the collection and visualization of CF data to extract additional biological significance and find novel therapeutic targets. Here, we present the CyFi-MAP—a disease map repository of CFTR molecular mechanisms and pathways involved in CF. Specifically, we represented the wild-type (wt-CFTR) and the F508del associated processes (F508del-CFTR) in separate submaps, with pathways related to protein biosynthesis, endoplasmic reticulum retention, export, activation/inactivation of channel function, and recycling/degradation after endocytosis. CyFi-MAP is an open-access resource with specific, curated and continuously updated information on CFTR-related pathways available online at https://cysticfibrosismap.github.io/. This tool was developed as a reference CF pathway data repository to be continuously updated and used worldwide in CF research.

Data de Publicação
2021-11-15

Suporte
Scientific Reports

Identificadores da Publicação
ISSN - 2045-2322

Editora
Springer Science and Business Media LLC

Volume
11
Fascículo
1

Identificadores do Documento
DOI - https://doi.org/10.1038/s41598-021-01618-3
URL - http://dx.doi.org/10.1038/s41598-021-01618-3

Identificadores de Qualidade
Web Of Science Q1 (2020) - 4.38 - MULTIDISCIPLINARY SCIENCES - SCIE
SCIMAGO Q1 (2020) - 1.24 - Multidisciplinary
Web Of Science Q1 (2019) - 3.998 - MULTIDISCIPLINARY SCIENCES - SCIE
SCOPUS Q1 (2019) - 7.2 - Multidisciplinary
SCIMAGO Q1 (2019) - 1.341 - Multidisciplinary
SCOPUS Q1 (2020) - 7.1 - Multidisciplinary


Exportar referência

APA
Catarina Pereira, Alexander Mazein, Carlos M. Farinha, Michael A. Gray, Karl Kunzelmann, Marek Ostaszewski, Irina Balaur, Margarida D. Amaral, Andre O. Falcao, (2021). CyFi-MAP: an interactive pathway-based resource for cystic fibrosis. Scientific Reports, 11, ISSN 2045-2322. eISSN . http://dx.doi.org/10.1038/s41598-021-01618-3

IEEE
Catarina Pereira, Alexander Mazein, Carlos M. Farinha, Michael A. Gray, Karl Kunzelmann, Marek Ostaszewski, Irina Balaur, Margarida D. Amaral, Andre O. Falcao, "CyFi-MAP: an interactive pathway-based resource for cystic fibrosis" in Scientific Reports, vol. 11, 2021. 10.1038/s41598-021-01618-3

BIBTEX
@article{53065, author = {Catarina Pereira and Alexander Mazein and Carlos M. Farinha and Michael A. Gray and Karl Kunzelmann and Marek Ostaszewski and Irina Balaur and Margarida D. Amaral and Andre O. Falcao}, title = {CyFi-MAP: an interactive pathway-based resource for cystic fibrosis}, journal = {Scientific Reports}, year = 2021, volume = 11 }