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Publications for cmfarinha (100)

2025
Personalized therapy with CFTR modulators: Response of p.Ile148Asn variant (2025)
Cláudia S Rodrigues et al., with 6 authors including:
Carlos M Farinha
Margarida D Amaral
Journal articles
2024
LMTK2 switches on canonical TGF-β1 signaling in human bronchial epithelial cells (2024)
Daniel F. Cruz et al., with 8 authors including:
Carlos M. Farinha
Journal articles
2024
E-learning within the European cystic fibrosis society - A multidisciplinary cross-sectional survey (2024)
C. Smith
H.K. Chadwick
K. Hill
D.G. Peckham
C.M.Farinha
Journal articles
2024
Disrupting the TGF-β–Wnt Balance to Control the Polarity of the Cystic Fibrosis Airway Epithelium (2024)
Carlos M. Farinha
Journal articles
2024
Cell type-specific regulation of CFTR trafficking—on the verge of progress (2024)
Carlos M. Farinha
Lúcia Santos
João F. Ferreira
Journal articles
2024
Characterization of rare CFTR mutations (2024)
Rego, Frederico Santos de Mello do
Farinha, Carlos Miguel Ribeiro da Silva
Academic documents
2023
Systems Biology and the New Omics (2023)
Margarida D. Amaral
Luka A. Clarke
Carlos M. Farinha
Hugo M. Botelho
Book chapters
2023
Use of adenine base editing and homology-independent targeted integration strategies to correct the cystic fibrosis causing variant, W1282X (2023)
Karen Mention et al., with 13 authors including:
Carlos M Farinha
Journal articles
2023
Personalized medicine: Function of CFTR variant p.Arg334Trp is rescued by currently available CFTR modulators (2023)
Violeta Railean et al., with 8 authors including:
Violeta Railean
Sofia S. Ramalho
Iris A. L. Silva
Carlos M. Farinha
Ines Pankonien
Margarida D. Amaral
Journal articles
2023
Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells (2023)
Lúcia Santos et al., with 8 authors including:
Margarida D. Amaral
Margarida Gama-Carvalho
Carlos M. Farinha
Journal articles
2023
Rescue of Rare CFTR Trafficking Mutants Highlights a Structural Location-Dependent Pattern for Correction (2023)
Sónia Zacarias
Marta S. P. Batista
Sofia S. Ramalho
Bruno L. Victor
Carlos M. Farinha
Journal articles
2023
Orphan CFTR Mutations : From disease mechanisms to novel therapeutic opportunities (2023)
Ramalho, Sofia Santos
Farinha, Carlos M.
Amaral, Margarida D.
Falcão, André O.
Academic documents
2022
Fundamental and translational research in Cystic Fibrosis – why we still need it (2022)
Carlos M. Farinha
Jeffrey L. Brodsky
Nicoletta Pedemonte
Journal articles
2022
Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids (2022)
João F. Ferreira
Iris A. L. Silva
Hugo M. Botelho
Margarida D. Amaral
Carlos M. Farinha
Journal articles
2022
Molecular mechanisms of cystic fibrosis – how mutations lead to misfunction and guide therapy (2022)
Carlos M. Farinha
Isabelle Callebaut
Journal articles
2022
Severity of the S1251N allele in cystic fibrosis is affected by the presence of the F508C variant in cis (2022)
Senne Cuyx et al., with 17 authors including:
Carlos M. Farinha
Journal articles
2022
Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A (2022)
Miquéias Lopes-Pacheco et al., with 10 authors including:
Miquéias Lopes-Pacheco
Carlos M. Farinha
Margarida D. Amaral
Journal articles
2022
Comparison of Cas9 and Cas12a CRISPR editing methods to correct the W1282X-CFTR mutation (2022)
Lúcia Santos et al., with 8 authors including:
Miquéias Lopes-Pacheco
Carlos M Farinha
Journal articles
2022
Novel cell models to study Cystic Fibrosis : from disease mechanisms to new therapeutic approaches (2022)
Santos, Lúcia Alexandra Rosa dos
Farinha, Carlos Miguel
Harrison, Patrick T.
Academic documents
2022
Biological impact of magnetic nanoparticles (2022)
Lima, Wilmara Vieira
Farinha, Carlos
Academic documents
2021
Rare Trafficking CFTR Mutations Involve Distinct Cellular Retention Machineries and Require Different Rescuing Strategies (2021)
Sofia S. Ramalho
Iris A. L. Silva
Margarida D. Amaral
Carlos M. Farinha
Journal articles
2021
Revisiting CFTR Interactions: Old Partners and New Players (2021)
Carlos M. Farinha
Martina Gentzsch
Journal articles
2021
Integrity and Stability of PTC Bearing CFTR mRNA and Relevance to Future Modulator Therapies in Cystic Fibrosis (2021)
Luka A. Clarke et al., with 6 authors including:
Luka A. Clarke
Carlos M. Farinha
Margarida D. Amaral
Journal articles
2021
CyFi-MAP: an interactive pathway-based resource for cystic fibrosis (2021)
Catarina Pereira et al., with 9 authors including:
Carlos M. Farinha
Margarida D. Amaral
Andre O. Falcao
Journal articles
2021
Differential Gene Expression Analysis Reveals Global LMTK2 Regulatory Network and Its Role in TGF-?1 Signaling (2021)
Daniel F. Cruz
Nilay Mitash
Fangping Mu
Carlos M. Farinha
Agnieszka Swiatecka-Urban
Journal articles
2020
In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry (2020)
Vera F. C. Ferreira et al., with 8 authors including:
Carlos M. Farinha
Journal articles
2020
Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A>G (2020)
Iris A.L. Silva et al., with 14 authors including:
Iris A.L. Silva
Luka A. Clarke
Violeta Railean
Hugo M. Botelho
Carlos M. Farinha
Margarida D. Amaral
Journal articles
2020
New Molecular Imaging Tools for Cystic Fibrosis (2020)
Carlos Miguel Farinha
Filipa Fernandes Mendes
Vera Ferreira
Academic documents
2020
From disease mechanisms to novel therapies and back (2020)
Carlos M. Farinha
Journal articles
2020
Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation (2020)
João D. Santos et al., with 6 authors including:
Francisco R. Pinto
Margarida D. Amaral
Carlos M. Farinha
Journal articles
2020
Full Rescue of F508del-CFTR Processing and Function by CFTR Modulators Can Be Achieved by Removal of Two Regulatory Regions (2020)
Inna Uliyakina et al., with 8 authors including:
Inna Uliyakina
Hugo M. Botelho
Sara Afonso
Carlos M. Farinha
Margarida D. Amaral
Journal articles
2020
Improved Fmoc?solid?phase peptide synthesis of an extracellular loop of CFTR for antibody selection by the phage display technology (2020)
Vera F.C. Ferreira
João D.G. Correia
Carlos M. Farinha
Filipa Mendes
Journal articles
2020
Mechanical Properties of Human Bronchial Epithelial Cells Expressing Wt- and Mutant CFTR (2020)
Ana P. Carapeto et al., with 7 authors including:
Ana P. Carapeto
Miguel V. Vitorino
Mário S. Rodrigues
Carlos M. Farinha
Journal articles
2020
The bidirectional relationship between CFTR and lipids (2020)
Kirsten A. Cottrill
Carlos M. Farinha
Nael A. McCarty
Journal articles
2020
Exploring the basic mechanisms in Cystic Fibrosis: Promoting data presentation and discussion at the 16th ECFS Basic Science Conference (2020)
Isabelle Callebaut
Martin Mense
Carlos M. Farinha
Journal articles
2020
TGF-?1 Augments the Apical Membrane Abundance of Lemur Tyrosine Kinase 2 to Inhibit CFTR-Mediated Chloride Transport in Human Bronchial Epithelia (2020)
Daniel F. Cruz
Nilay Mitash
Carlos M. Farinha
Agnieszka Swiatecka-Urban
Journal articles
2020
Modulation of the aggregation pathway of a model variant form of human phenylalanine hydroxylase: towards the development of a new class of pharmacological chaperones for the treatment of phenylketonuria (2020)
Alice da Cruz Madeira Borges
Ana Paula Leandro
Carlos Farinha
Academic documents
2020
Regulation of the TGF-B1 signaling in cystic fibrosis: the role of LMTK2 (2020)
Daniel Filipe Soares Pereira da Cruz
Carlos Miguel Farinha
Agnieszka Swiatecka-Urban
Academic documents
2020
Regulation of CFTR membrane stability - crosstalk between signalling pathways and the cytoskeleton (2020)
João Frederico Santos Fernandes e Coelho Ferreira
Carlos Miguel Ribeiro da Silva Farinha
Academic documents
2019
Cytoskeleton Regulators Associate with CFTR to Control Its Membrane Levels Under EPAC1 Activation (2019)
Carlos M Farinha
Conference papers
2019
Omics in CF – Where are we now? (2019)
Carlos M. Farinha
Journal articles
2019
Network Biology Identifies Novel Regulators of CFTR Trafficking and Membrane Stability (2019)
Cláudia Almeida Loureiro et al., with 7 authors including:
Paulo Matos
Carlos M. Farinha
Francisco R. Pinto
Journal articles
2019
Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum (2019)
João D. Santos et al., with 9 authors including:
Hugo M. Botelho
Margarida D. Amaral
Andre O. Falcao
Carlos M. Farinha
Journal articles
2019
Gene and Base Edited Cell Models of Cystic-Fibrosis Causing Mutations (2019)
Carlos M Farinha
Lúcia Santos
Conference papers
2019
R560S: A class II CFTR mutation that is not rescued by current modulators (2019)
Nikhil T. Awatade et al., with 10 authors including:
Hugo M. Botelho
Carlos M. Farinha
Margarida D. Amaral
Journal articles
2019
Unraveling the Function of Lemur Tyrosine Kinase 2 Network (2019)
Daniel F. Cruz
Carlos M. Farinha
Agnieszka Swiatecka-Urban
Journal articles
2019
A machine learning based drug discovery pipeline: finding new therapies for Cystic Fibrosis (2019)
Paulo Nuno Hilário Teixeira de Sousa
Falcão, André Osório e Cruz de Azerêdo
Farinha, Carlos
Academic documents
2019
Regulation of CFTR trafficking and membrane anchoring: new insights into cAMP signalling (2019)
Santos, João Filipe Delgado dos
Farinha, Carlos M.
Zaccolo, Manuela
Academic documents
2018
Astrocytic CB1R-mediated calcium signalling: impact in glutamate transport and interaction with adenosine receptors (2018)
Joana Filipa Gonçalves Ribeiro
Sandra Cristina Henriques Vaz
Carlos Farinha
Academic documents
2018
UNDERSTANDING THE REGULATION OF TGF-?1 SIGNALING PATHWAY IN CYSTIC FIBROSIS: THE ROLE OF PP1 AND LMTK2 (2018)
DF Cruz
M Kohn
CM Farinha
A Swiatecka-Urban
Conference papers
2018
Proteomic interaction profiling reveals KIFC1 as a factor involved in early targeting of F508del-CFTR to degradation (2018)
Sara Canato et al., with 8 authors including:
Margarida D. Amaral
André O. Falcao
Carlos M. Farinha
Journal articles
2018
Targeting of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein with a Technetium-99m Imaging Probe (2018)
Vera F. C. Ferreira et al., with 6 authors including:
Carlos M. Farinha
Journal articles
2018
WS15.1 From the bench to bedside: expanding CFTR modulators to rare mutations by response assessment in patients-derived materials and cellular models (2018)
I.A.L. Silva et al., with 6 authors including:
C.M. Farinha
M.D. Amaral
Conference papers
2018
Protein and lipid interactions – Modulating CFTR trafficking and rescue (2018)
Carlos M. Farinha
Elizabeth Miller
Nael McCarty
Journal articles
2018
Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule (2018)
Jia Liu et al., with 14 authors including:
Carlos M Farinha
Margarida D Amaral
Journal articles
2018
Rab GTPases regulate the trafficking of channels and transporters – a focus on cystic fibrosis (2018)
Carlos M. Farinha
Paulo Matos
Journal articles
2018
CFTR and Cystic Fibrosis (2018)
Carlos M. Farinha
Books
2017
Characterization of orphan CFTR mutations (2017)
Sofia Santos Ramalho
Farinha, Carlos
Amaral, Margarida
Academic documents
2017
FUNCTIONAL AND BIOCHEMICAL ASSESSMENT OF CORRECTORS AND POTENTIATORS ON THE RARE CYSTIC FIBROSIS-CAUSING R560S MUTATION (2017)
NT Awatade et al., with 10 authors including:
CM Farinha
Conference papers
2017
WS09.2 Modulation of protein traffic networks to rescue F508del-CFTR from the endoplasmic reticulum (2017)
S. Canato et al., with 8 authors including:
M.D. Amaral
A. Falcão
C.M. Farinha
Conference papers
2017
EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1 (2017)
Miguel J. Lobo
Margarida D. Amaral
Manuela Zaccolo
Carlos M. Farinha
Journal articles
2017
From the endoplasmic reticulum to the plasma membrane: mechanisms of CFTR folding and trafficking (2017)
Carlos M. Farinha
Sara Canato
Journal articles
2016
IDENTIFICATION OF PROTEIN FACTORS THAT REGULATE CFTR EXIT FROM THE ENDOPLASMIC RETICULUM (2016)
S Canato et al., with 7 authors including:
CM Farinha
Conference papers
2016
Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity (2016)
Carlos M. Farinha
Agnieszka Swiatecka-Urban
David L. Brautigan
Peter Jordan
Journal articles
2016
Investigating Alternative Transport of Integral Plasma Membrane Proteins from the ER to the Golgi: Lessons from the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) (2016)
Margarida D. Amaral
Carlos M. Farinha
Paulo Matos
Hugo M. Botelho
Book chapters
2016
Repairing the basic defect in cystic fibrosis - one approach is not enough (2016)
Carlos M. Farinha
Paulo Matos
Journal articles
2015
Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis (2015)
Nikhil T. Awatade et al., with 9 authors including:
Carlos M. Farinha
Luka A. Clarke
Margarida D. Amaral
Journal articles
2015
TGF-beta SIGNALING IN CYSTIC FIBROSIS - A ROLE FOR LMTK2 AND PP1C (2015)
Farinha, CM et al., with 8 authors including:
Farinha, CM
Conference papers
2014
Cystic fibrosis - new molecular imaging tools (2014)
Ferreira, Vera FC et al., with 6 authors including:
Farinha, CM
Journal articles
2014
LMTK2 Mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells (2014)
Simão Luz et al., with 6 authors including:
Margarida D. Amaral
Carlos M. Farinha
Journal articles
2014
EPAC1 - EXCHANGE PROTEIN ACTIVATED BY CYCLIC AMP - IS A NOVEL PLAYER IN CFTR REGULATION BY CYCLIC AMP AT THE CELL SURFACE (2014)
Lobo, M
Amaral, MD
Farinha, CM
Journal articles
2014
Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D-CFTR (2014)
Zhe Xu et al., with 8 authors including:
Carlos M. Farinha
Margarida D. Amaral
Journal articles
2013
Revertants, Low Temperature, and Correctors Reveal the Mechanism of F508del-CFTR Rescue by VX-809 and Suggest Multiple Agents for Full Correction (2013)
Carlos M. Farinha et al., with 11 authors including:
Carlos M. Farinha
Bárbara J. Henriques
Cláudio M. Gomes
Margarida D. Amaral
Journal articles
2013
LMTK2 Regulates CFTR Endocytosis by Phosphorylation at CFTR Ser-737. (2013)
Luz S et al., with 7 authors including:
Amaral MD
Farinha CM
Journal articles
2013
Exchange Proteins Directly Activated by Cyclic AMP: Novel CFTR Interactors? (2013)
Fernandes J
Amaral MD
Farinha CM
Journal articles
2013
Screening for Novel F508del-CFTR Correctors Identified by Pharmacophore Modelling through automated microscopy and NBD1 Folding Assays. (2013)
Dahimène S et al., with 11 authors including:
Farinha CM
Amaral MD
Conference papers
2013
Rescuing Strategies of the most common Cystic Fibrosis mutant act at distinct ER conformational checkpoints. (2013)
Farinha CM et al., with 6 authors including:
Farinha CM
Amaral MD
Conference papers
2013
Revertants, Low temperature and Correctors Provide Clues to Mechanism of F508del-CFTR Rescue by VX-809 and Suggest Multiple Agents for Full Correction. (2013)
Farinha CM et al., with 9 authors including:
Farinha CM
Amaral MD
Conference papers
2013
Exchange Proteins Directly Activated by Cyclic AMP: Novel CFTR Interactors? (2013)
Fernandes J, Amaral, MD, Farinha CM
Farinha CM
Conference papers
2013
Understanding protein folding and trafficking: the model of Cystic Fibrosis (2013)
Farinha CM
Conference papers
2013
Control of CFTR membrane trafficking: not just from the ER to the Golgi (2013)
Farinha CM
Matos P
Amaral MD
Journal articles
2013
CFTR Post-translational Modifications and Signalling: Lessons from a Model Protein and Roles in Cystic Fibrosis Disease (2013)
Amaral MD
Farinha CM
Journal articles
2013
CFTR mutations altering CFTR fragmentation (2013)
Kendra Tosoni et al., with 11 authors including:
Margarida D. Amaral
Carlos M. Farinha
Journal articles
2013
EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CYCLIC AMP (EPAC) - A NOVEL CFTR INTERACTOR (2013)
Fernandes, J
Amaral, MD
Farinha, CM
Journal articles
2013
Rescuing mutant CFTR: a multi-task approach to a better outcome in treating Cystic Fibrosis (2013)
Amaral MD
Farinha CM
Journal articles
2012
Structural and functional characterization of the bacterial ferrous homeostasis protein FeoA (2012)
Vieira, Vanessa Cistina de Carvalho
Matzapetakis, Manolis
Farinha, Carlos
Academic documents
2012
BAG-1 Stabilizes Mutant F508del-CFTR in a Ubiquitin-Like-Domain-Dependent Manner (2012)
Mendes F et al., with 6 authors including:
Farinha CM
Amaral MD
Journal articles
2012
Biological relevance of mucoid vs. nonmucoid morphotype variation by Burkholderia cepacia complex (2012)
Tavares, Andreia Filipa Campos
Moreira, Leonilde
Farinha, Carlos
Academic documents
2012
Regulation of ENaC biogenesis by the stress response protein SERP1 (2012)
Diana Faria et al., with 14 authors including:
Carlos Miguel Farinha
Margarida D. Amaral
Journal articles
2012
LMTK2 facilitates CFTR endocytosis by phosphorylation at CFTR Ser-737 residue (2012)
Cunha da Luz, S. et al., with 7 authors including:
Amaral, M. D.
Farinha CM
Journal articles
2012
Molecular switches in CFTR processing and trafficking: the role of the novel interactor Rap1A (2012)
Fernandes, João Miguel Parente
Farinha, Carlos
Academic documents
2012
Regulação dos níveis de transportadores de cloreto na membrana plasmática de células renais pela nova via de sinalização WNK4/Syk (2012)
Loureiro, Cláudia Almeida
Jordan, Peter
Farinha, Carlos
Academic documents
2010
Caracterização bioquímica e funcional de complexos proteicos associados ao 3’UTR de mRNAs alvo (2010)
Oliveira, Mariana Colino de
Carvalho, Margarida Henriques da Gama
Farinha, Carlos
Academic documents
2009
Phosphorylation of CFTR and Other Membrane Proteins: a Role in Biogenesis and Traffic? (2009)
Romeiras, Francisco
Farinha, Carlos M
Academic documents
2008
Novel insight into CFTR phosphorylation: implications for its processing, trafficking and function (2008)
Luz, Simão Filipe Cunha da
Farinha, Carlos Miguel Ribeiro da Silva
Academic documents
2007
Teaching biochemistry at Lisbon University - Facing the challenge of the Bologna declaration in the 25th anniversary of the biochemistry course. (2007)
Farinha, C.M.
Ponces Freire, A..
Journal articles
2005
Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin (2005)
Farinha CM
Amaral MD
Journal articles
2004
Methods for RNA extraction, cDNA preparation and analysis of CFTR transcripts (2004)
Anabela S. Ramalho et al., with 11 authors including:
Carlos M. Farinha
Luka A. Clarke
Margarida D. Amaral
Journal articles
2004
A comparison of 14 antibodies for the biochemical detection of the cystic fibrosis transmembrane conductance regulator protein (2004)
Farinha CM
Mendes F
Roxo-Rosa M
Penque D
Amaral MD
Journal articles
1999
Cystic fibrosis patients with the 3272-26A-->G mutation have mild disease, leaky alternative mRNA splicing, and CFTR protein at the cell membrane (1999)
Sebastian Beck et al., with 15 authors including:
Carlos Farinha
Margarida D. Amaral
Journal articles