BIBLIOS

Document type
Journal articles

Document subtype
Full paper

Title
Unboxing mutations: Connecting mutation types with evolutionary consequences

Participants in the publication
Emma L. Berdan (Author)
Alexandre Blanckaert (Author)
Tanja Slotte (Author)
Alexander Suh (Author)
Anja M. Westram (Author)
Inês Fragata (Author)
Dep. Biologia Animal
cE3c

Summary
A key step in understanding the genetic basis of different evolutionary outcomes (e.g., adaptation) is to determine the roles played by different mutation types (e.g., SNPs, translocations and inversions). To do this we must simultaneously consider different mutation types in an evolutionary framework. Here, we propose a research framework that directly utilizes the most important characteristics of mutations, their population genetic effects, to determine their relative evolutionary significance in a given scenario. We review known population genetic effects of different mutation types and show how these may be connected to different evolutionary outcomes. We provide examples of how to implement this framework and pinpoint areas where more data, theory and synthesis are needed. Linking experimental and theoretical approaches to examine different mutation types simultaneously is a critical step towards understanding their evolutionary significance.


Institution
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Where published
Molecular Ecology

Publication Identifiers
ISSN - 0962-1083

Publisher
Wiley



Document Identifiers
DOI - https://doi.org/10.1111/mec.15936
URL - http://dx.doi.org/10.1111/mec.15936