BIBLIOS

Tipo
Artigos em Revista

Tipo de Documento
Artigo Completo

Título
Unboxing mutations: Connecting mutation types with evolutionary consequences

Participantes na publicação
Emma L. Berdan (Author)
Alexandre Blanckaert (Author)
Tanja Slotte (Author)
Alexander Suh (Author)
Anja M. Westram (Author)
Inês Fragata (Author)
Dep. Biologia Animal
cE3c

Resumo
A key step in understanding the genetic basis of different evolutionary outcomes (e.g., adaptation) is to determine the roles played by different mutation types (e.g., SNPs, translocations and inversions). To do this we must simultaneously consider different mutation types in an evolutionary framework. Here, we propose a research framework that directly utilizes the most important characteristics of mutations, their population genetic effects, to determine their relative evolutionary significance in a given scenario. We review known population genetic effects of different mutation types and show how these may be connected to different evolutionary outcomes. We provide examples of how to implement this framework and pinpoint areas where more data, theory and synthesis are needed. Linking experimental and theoretical approaches to examine different mutation types simultaneously is a critical step towards understanding their evolutionary significance.


Instituição
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Suporte
Molecular Ecology

Identificadores da Publicação
ISSN - 0962-1083

Editora
Wiley



Identificadores do Documento
DOI - https://doi.org/10.1111/mec.15936
URL - http://dx.doi.org/10.1111/mec.15936