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Publication details

Document type
Journal articles

Document subtype
Full paper

Title
Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A Step Forward

Participants in the publication
Mariana Amaral (Author)
Adília J. Charmier (Author)
Ricardo A. Afonso (Author)
José Catarino (Author)
Pedro Faísca (Author)
Lina Carvalho (Author)
Lia Ascensão (Author)
Dep. Biologia Vegetal
CESAM-Ciências - Centro de Estudos do Ambiente e do Mar-Ciências
João M. P. Coelho (Author)
Dep. Física
LOLS - Laboratório de Óptica, Lasers e Sistemas
IBEB - Instituto de Biofísica e Engenharia Biomédica
M. Manuela Gaspar (Author)
Catarina Pinto Reis (Author)

Scope
International

Refereeing
Yes

Summary
Anaplastic thyroid carcinoma (ATC) is a subtype of thyroid cancer that generally\ndoes not respond to the available treatments, making it one of the most lethal cancers known. As\nan alternative, Photothermal Therapy (PTT) can be considered a promising strategy. In this case,\ngold nanoparticles (AuNPs) are activated when irradiated by light, enhancing the local temperature,\nresulting in cell death. Thus, this study aims to formulate AuNPs specifically for targeting PTT to\nATC. For this, biocompatible AuNPs were designed and functionalized with ATC-specific ligands\n(holo-transferrin, epidermal growth factor (EGF), and lapatinib), showing optimal physicochemical properties. Safety, efficacy, and ATC specificity were determined in vitro. Holo-transferrin\nfunctionalized-AuNPs were the most effective for PTT against ATC. Safety and biodistribution\nwere studied in vivo, proving that the formulation was safe for intratumoural administration. So,\ntaking these results all together, AuNPs-mediated-PTT seems to be a promising hint to find a viable\ntreatment for ATC.

Date of Submisson/Request
2021-02-22
Date of Acceptance
2021-03-8
Date of Publication
2021-03-12

Where published
Cancers

Publication Identifiers
ISSN - 2072-6694

Publisher
MDPI AG

Volume
13
Number
6

Starting page
1242

Document Identifiers
DOI - https://doi.org/10.3390/cancers13061242
URL - http://dx.doi.org/10.3390/cancers13061242

Rankings
SCIMAGO Q1 (2019) - 1.938 - Cancer Research

Keywords
anaplastic thyroid carcinoma photothermal therapy novel therapies gold nanoparticles


Export

APA
Mariana Amaral, Adília J. Charmier, Ricardo A. Afonso, José Catarino, Pedro Faísca, Lina Carvalho, Lia Ascensão, João M. P. Coelho, M. Manuela Gaspar, Catarina Pinto Reis, (2021). Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A Step Forward. Cancers, 13, ISSN 2072-6694. eISSN . http://dx.doi.org/10.3390/cancers13061242

IEEE
Mariana Amaral, Adília J. Charmier, Ricardo A. Afonso, José Catarino, Pedro Faísca, Lina Carvalho, Lia Ascensão, João M. P. Coelho, M. Manuela Gaspar, Catarina Pinto Reis, "Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A Step Forward" in Cancers, vol. 13, 2021. 10.3390/cancers13061242

BIBTEX
@article{49581, author = {Mariana Amaral and Adília J. Charmier and Ricardo A. Afonso and José Catarino and Pedro Faísca and Lina Carvalho and Lia Ascensão and João M. P. Coelho and M. Manuela Gaspar and Catarina Pinto Reis}, title = {Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A Step Forward}, journal = {Cancers}, year = 2021, volume = 13 }