BIBLIOS

Document type
Journal articles

Document subtype
Full paper

Title
Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A Step Forward

Participants in the publication
Mariana Amaral (Author)
Adília J. Charmier (Author)
Ricardo A. Afonso (Author)
José Catarino (Author)
Pedro Faísca (Author)
Lina Carvalho (Author)
Lia Ascensão (Author)
Dep. Biologia Vegetal
CESAM
João M. P. Coelho (Author)
Dep. Física
LOLS
IBEB
M. Manuela Gaspar (Author)
Catarina Pinto Reis (Author)

Summary
Anaplastic thyroid carcinoma (ATC) is a subtype of thyroid cancer that generally\ndoes not respond to the available treatments, making it one of the most lethal cancers known. As\nan alternative, Photothermal Therapy (PTT) can be considered a promising strategy. In this case,\ngold nanoparticles (AuNPs) are activated when irradiated by light, enhancing the local temperature,\nresulting in cell death. Thus, this study aims to formulate AuNPs specifically for targeting PTT to\nATC. For this, biocompatible AuNPs were designed and functionalized with ATC-specific ligands\n(holo-transferrin, epidermal growth factor (EGF), and lapatinib), showing optimal physicochemical properties. Safety, efficacy, and ATC specificity were determined in vitro. Holo-transferrin\nfunctionalized-AuNPs were the most effective for PTT against ATC. Safety and biodistribution\nwere studied in vivo, proving that the formulation was safe for intratumoural administration. So,\ntaking these results all together, AuNPs-mediated-PTT seems to be a promising hint to find a viable\ntreatment for ATC.


Where published
Cancers

Publication Identifiers
ISSN - 2072-6694

Publisher
MDPI AG



Document Identifiers
DOI - https://doi.org/10.3390/cancers13061242
URL - http://dx.doi.org/10.3390/cancers13061242

Rankings
SCIMAGO Q1 (2019) - 1.938 - Cancer Research

Keywords
anaplastic thyroid carcinoma photothermal therapy novel therapies gold nanoparticles