BIBLIOS

Tipo
Artigos em Revista

Tipo de Documento
Artigo Completo

Título
Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A Step Forward

Participantes na publicação
Mariana Amaral (Author)
Adília J. Charmier (Author)
Ricardo A. Afonso (Author)
José Catarino (Author)
Pedro Faísca (Author)
Lina Carvalho (Author)
Lia Ascensão (Author)
Dep. Biologia Vegetal
CESAM
João M. P. Coelho (Author)
Dep. Física
LOLS
IBEB
M. Manuela Gaspar (Author)
Catarina Pinto Reis (Author)

Resumo
Anaplastic thyroid carcinoma (ATC) is a subtype of thyroid cancer that generally\ndoes not respond to the available treatments, making it one of the most lethal cancers known. As\nan alternative, Photothermal Therapy (PTT) can be considered a promising strategy. In this case,\ngold nanoparticles (AuNPs) are activated when irradiated by light, enhancing the local temperature,\nresulting in cell death. Thus, this study aims to formulate AuNPs specifically for targeting PTT to\nATC. For this, biocompatible AuNPs were designed and functionalized with ATC-specific ligands\n(holo-transferrin, epidermal growth factor (EGF), and lapatinib), showing optimal physicochemical properties. Safety, efficacy, and ATC specificity were determined in vitro. Holo-transferrin\nfunctionalized-AuNPs were the most effective for PTT against ATC. Safety and biodistribution\nwere studied in vivo, proving that the formulation was safe for intratumoural administration. So,\ntaking these results all together, AuNPs-mediated-PTT seems to be a promising hint to find a viable\ntreatment for ATC.


Suporte
Cancers

Identificadores da Publicação
ISSN - 2072-6694

Editora
MDPI AG



Identificadores do Documento
DOI - https://doi.org/10.3390/cancers13061242
URL - http://dx.doi.org/10.3390/cancers13061242

Identificadores de Qualidade
SCIMAGO Q1 (2019) - 1.938 - Cancer Research

Keywords
anaplastic thyroid carcinoma photothermal therapy novel therapies gold nanoparticles