Document type
Academic documents
Document subtype
PhD thesis
Title
Efficient, Dependable Storage of Human Genome Sequencing Data
Participants in the publication
Vinicius Vielmo Cogo (Author)
Dep. Informática
LASIGE
Alysson Neves Bessani (Adviser)
Dep. Informática
LASIGE
Summary
The understanding of human genome impacts several areas of human life. Data from human genomes is massive because there are millions of samples to be sequenced, and each sequenced human genome may size hundreds of gigabytes. Human genomes are critical because they are extremely valuable to research and may provide hints on individuals’ health\\nstatus, identify their donors, or reveal information about donors’ relatives. Their size and criticality, plus the amount of data being produced by medical and life-sciences institutions, require systems to scale while being secure, dependable, auditable, and affordable. Current storage infrastructures are too expensive to ignore cost efficiency in storing human genomes, and they lack the proper knowledge and mechanisms to protect the privacy of sample donors. This thesis proposes an efficient storage system for human genomes that medical and life-sciences institutions may trust and afford. It enhances traditional storage ecosystems with privacy-aware, data-reduction, and auditability techniques to enable the efficient, dependable use of multi-tenant infrastructures to store human genomes. Contributions from this thesis include (1) a study on the privacy-sensitivity of human genomes; (2) to detect genomes’ privacy-sensitive portions systematically; (3) specialised data reduction algorithms for sequencing data; (4) an independent auditability scheme for secure dispersed storage; and (5) a complete storage pipeline that obtains reasonable privacy protection, security, and dependability guarantees at modest costs (e.g., less than $1/Genome/Year) by integrating the proposed mechanisms with appropriate storage configurations.
Date of Publication
2020-09-08
Institution
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA
Publication Identifiers
Document Identifiers
URL -
https://repositorio.ul.pt/handle/10451/49766
Download