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Publication details

Document type
Book chapters


Title
Riboflavin (vitamin B2) and mitochondrial energy

Participants in the publication
Bárbara J. Henriques (Author)
Dep. Química e Bioquímica
BIOISI - Instituto de Biossistemas e Ciências Integrativas
Cláudio M. Gomes (Author)
Dep. Química e Bioquímica
BIOISI - Instituto de Biossistemas e Ciências Integrativas

Scope
International

Summary
Vitamin B2, also known as riboflavin, is the precursor of two important redox cofactors, flavin adenine dinucleotide and flavin mononucleotide, making it vital for cells and mitochondrial energy production. These two flavins are essential cofactors for the structure and function of several mitochondrial flavoproteins including membrane-bound respiratory chain (RC) complexes and β-oxidation enzymes from the mitochondrial matrix. The aim of this chapter is to describe the importance of vitamin B2 as a vital biomolecule for the correct structure and function of mitochondrial flavoproteins, and consequently for maintenance of the mitochondrial energy production status. We will focus on enzymes associated with energy deficiency pathologies such as fatty acid oxidation disorders and RC deficiencies. For these pathologies, we will provide examples of reported clinical cases that benefit from therapeutic riboflavin supplementation through oral intake and discuss potential molecular mechanisms underlying its beneficial effects.

Editor(s)
Vinood B. Patel

Date of Publication
2020

Institution
Biosystems & Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Portugal

Where published
Molecular Nutrition: Vitamins

Publication Identifiers
ISBN - 9780128119075

Publisher
Elsevier

Edition
First

Number of pages
19
Starting page
225
Last page
244

Document Identifiers
DOI - https://doi.org/10.1016/b978-0-12-811907-5.00011-7
URL - http://dx.doi.org/10.1016/b978-0-12-811907-5.00011-7


Export

APA
Bárbara J. Henriques, Cláudio M. Gomes, (2020). Riboflavin (vitamin B2) and mitochondrial energy. Molecular Nutrition: Vitamins, 225-244

IEEE
Bárbara J. Henriques, Cláudio M. Gomes, "Riboflavin (vitamin B2) and mitochondrial energy" in Molecular Nutrition: Vitamins, 2020, pp. 225-244

BIBTEX
@incollection{41966, author = {Bárbara J. Henriques and Cláudio M. Gomes}, title = {Riboflavin (vitamin B2) and mitochondrial energy}, booktitle = {Molecular Nutrition: Vitamins}, year = 2020, pages = {225-244}, address = {}, publisher = {Elsevier} }