BIBLIOS

Tipo
Capítulo em Livro


Título
Riboflavin (vitamin B2) and mitochondrial energy

Participantes na publicação
Bárbara J. Henriques (Author)
Dep. Química e Bioquímica
BioISI
Cláudio M. Gomes (Author)
Dep. Química e Bioquímica
BioISI

Resumo
Vitamin B2, also known as riboflavin, is the precursor of two important redox cofactors, flavin adenine dinucleotide and flavin mononucleotide, making it vital for cells and mitochondrial energy production. These two flavins are essential cofactors for the structure and function of several mitochondrial flavoproteins including membrane-bound respiratory chain (RC) complexes and β-oxidation enzymes from the mitochondrial matrix. The aim of this chapter is to describe the importance of vitamin B2 as a vital biomolecule for the correct structure and function of mitochondrial flavoproteins, and consequently for maintenance of the mitochondrial energy production status. We will focus on enzymes associated with energy deficiency pathologies such as fatty acid oxidation disorders and RC deficiencies. For these pathologies, we will provide examples of reported clinical cases that benefit from therapeutic riboflavin supplementation through oral intake and discuss potential molecular mechanisms underlying its beneficial effects.

Editor
Vinood B. Patel


Instituição
Biosystems & Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Portugal

Suporte
Molecular Nutrition: Vitamins

Identificadores da Publicação
ISBN - 9780128119075

Editora
Elsevier



Identificadores do Documento
DOI - https://doi.org/10.1016/b978-0-12-811907-5.00011-7
URL - http://dx.doi.org/10.1016/b978-0-12-811907-5.00011-7