BIBLIOS

Document type
Journal articles

Document subtype
Full paper

Title
Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease

Participants in the publication
Joana S. Cristóvão (Author)
BioISI - Biosystems & Integrative Sciences Institute
Renata Santos (Author)
Cláudio M. Gomes (Author)
Dep. Química e Bioquímica
BioISI

Summary
Alzheimer’s disease (AD) is the most prevalent age-related dementia affecting millions of people worldwide. Its main pathological hallmark feature is the formation of insoluble protein deposits of amyloid-β and hyperphosphorylated tau protein into extracellular plaques and intracellular neurofibrillary tangles, respectively. Many of the mechanistic details of this process remain unknown, but a well-established consequence of protein aggregation is synapse dysfunction and neuronal loss in the AD brain. Different pathways including mitochondrial dysfunction, oxidative stress, inflammation, and metal metabolism have been suggested to be implicated in this process. In particular, a body of evidence suggests that neuronal metal ions such as copper, zinc, and iron play important roles in brain function in health and disease states and altered homeostasis and distribution as a common feature across different neurodegenerative diseases and aging. In this focused review, we overview neuronal proteins that are involved in AD and whose metal binding properties may underlie important biochemical and regulatory processes occurring in the brain during the AD pathophysiological process.


Institution
BioISI - Biosystems & Integrative Sciences Institute

Where published
Oxidative Medicine and Cellular Longevity

Publication Identifiers
ISSN - 1942-0900

Publisher
Hindawi Limited



Document Identifiers
DOI - https://doi.org/10.1155/2016/9812178
URL - http://dx.doi.org/10.1155/2016/9812178

Rankings
SCIMAGO Q1 (2016) - 1.547 - Biochemistry
SCIMAGO Q1 (2016) - 1.547 - Medicine (miscellaneous)
SCIMAGO Q1 (2017) - 1.558 - Biochemistry