BIBLIOS

Tipo
Artigos em Revista

Tipo de Documento
Artigo Completo

Título
Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease

Participantes na publicação
Joana S. Cristóvão (Author)
BioISI - Biosystems & Integrative Sciences Institute
Renata Santos (Author)
Cláudio M. Gomes (Author)
Dep. Química e Bioquímica
BioISI

Resumo
Alzheimer’s disease (AD) is the most prevalent age-related dementia affecting millions of people worldwide. Its main pathological hallmark feature is the formation of insoluble protein deposits of amyloid-β and hyperphosphorylated tau protein into extracellular plaques and intracellular neurofibrillary tangles, respectively. Many of the mechanistic details of this process remain unknown, but a well-established consequence of protein aggregation is synapse dysfunction and neuronal loss in the AD brain. Different pathways including mitochondrial dysfunction, oxidative stress, inflammation, and metal metabolism have been suggested to be implicated in this process. In particular, a body of evidence suggests that neuronal metal ions such as copper, zinc, and iron play important roles in brain function in health and disease states and altered homeostasis and distribution as a common feature across different neurodegenerative diseases and aging. In this focused review, we overview neuronal proteins that are involved in AD and whose metal binding properties may underlie important biochemical and regulatory processes occurring in the brain during the AD pathophysiological process.


Instituição
BioISI - Biosystems & Integrative Sciences Institute

Suporte
Oxidative Medicine and Cellular Longevity

Identificadores da Publicação
ISSN - 1942-0900

Editora
Hindawi Limited



Identificadores do Documento
DOI - https://doi.org/10.1155/2016/9812178
URL - http://dx.doi.org/10.1155/2016/9812178

Identificadores de Qualidade
SCIMAGO Q1 (2016) - 1.547 - Biochemistry
SCIMAGO Q1 (2016) - 1.547 - Medicine (miscellaneous)
SCIMAGO Q1 (2017) - 1.558 - Biochemistry