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Publication details

Document type
Journal articles

Document subtype
Full paper

Title
Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders

Participants in the publication
Bárbara J. Henriques (Author)
Dep. Química e Bioquímica
BIOISI - Instituto de Biossistemas e Ciências Integrativas
Tânia G. Lucas (Author)
Cláudio M. Gomes (Author)
Dep. Química e Bioquímica
BIOISI - Instituto de Biossistemas e Ciências Integrativas

Scope
International

Refereeing
Yes

Summary
Riboflavin, or vitamin B2, plays an important role in the cell as biological precursor of FAD and FMN, two important flavin cofactors which are essential for the structure and function of flavoproteins. Riboflavin has been used in therapeutic approaches of various inborn errors of metabolism, notably in metabolic disorders resulting either from defects in proteins involved in riboflavin metabolism and transport or from defects in flavoenzymes. The scope of this review is to provide an updated perspective of clinical cases in which riboflavin was used as a potential therapeutic agent in disorders affecting mitochondrial energy metabolism. In particular, we discuss available mechanistic insights on the role of riboflavin as a pharmacological chaperone for the recovery of misfolded metabolic flavoenzymes.

Date of Publication
2016-09-02

Institution
Biosystems & Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Portugal.

Where published
Current Drug Targets

Publication Identifiers
ISSN - 1389-4501

Publisher
Bentham Science Publishers Ltd.

Volume
17
Number
13

Number of pages
7
Starting page
1527
Last page
1534

Document Identifiers
URL - http://dx.doi.org/10.2174/1389450117666160813180812
DOI - https://doi.org/10.2174/1389450117666160813180812

Rankings
Web Of Science Q2 (2017) - 3.112 - PHARMACOLOGY & PHARMACY - SCIE
Web Of Science Q2 (2018) - 2.642 - PHARMACOLOGY & PHARMACY - SCIE

Keywords
Riboflavin-responsive flavoenzymes riboflavin transporters metabolic disorders mitochondrial beta-oxidation disorders respiratory chain deficiencies


Export

APA
Bárbara J. Henriques, Tânia G. Lucas, Cláudio M. Gomes, (2016). Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders. Current Drug Targets, 17, 1527-1534. ISSN 1389-4501. eISSN . http://dx.doi.org/10.2174/1389450117666160813180812

IEEE
Bárbara J. Henriques, Tânia G. Lucas, Cláudio M. Gomes, "Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders" in Current Drug Targets, vol. 17, pp. 1527-1534, 2016. 10.2174/1389450117666160813180812

BIBTEX
@article{40963, author = {Bárbara J. Henriques and Tânia G. Lucas and Cláudio M. Gomes}, title = {Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders}, journal = {Current Drug Targets}, year = 2016, pages = {1527-1534}, volume = 17 }