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Detalhes Referência

Tipo
Artigos em Revista

Tipo de Documento
Artigo Completo

Título
Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders

Participantes na publicação
Bárbara J. Henriques (Author)
Dep. Química e Bioquímica
BioISI
Tânia G. Lucas (Author)
Cláudio M. Gomes (Author)
Dep. Química e Bioquímica
BioISI

Resumo
Riboflavin, or vitamin B2, plays an important role in the cell as biological precursor of FAD and FMN, two important flavin cofactors which are essential for the structure and function of flavoproteins. Riboflavin has been used in therapeutic approaches of various inborn errors of metabolism, notably in metabolic disorders resulting either from defects in proteins involved in riboflavin metabolism and transport or from defects in flavoenzymes. The scope of this review is to provide an updated perspective of clinical cases in which riboflavin was used as a potential therapeutic agent in disorders affecting mitochondrial energy metabolism. In particular, we discuss available mechanistic insights on the role of riboflavin as a pharmacological chaperone for the recovery of misfolded metabolic flavoenzymes.

Data de Publicação
2016-09-02

Instituição
Biosystems & Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Portugal.

Suporte
Current Drug Targets

Identificadores da Publicação
ISSN - 1389-4501

Editora
Bentham Science Publishers Ltd.

Volume
17
Fascículo
13

Número de Páginas
7
Página Inicial
1527
Página Final
1534

Identificadores do Documento
URL - http://dx.doi.org/10.2174/1389450117666160813180812
DOI - https://doi.org/10.2174/1389450117666160813180812

Identificadores de Qualidade
Web Of Science Q2 (2017) - 3.112 - PHARMACOLOGY & PHARMACY - SCIE
Web Of Science Q2 (2018) - 2.642 - PHARMACOLOGY & PHARMACY - SCIE

Keywords
Riboflavin-responsive flavoenzymes riboflavin transporters metabolic disorders mitochondrial beta-oxidation disorders respiratory chain deficiencies


Exportar referência

APA
Bárbara J. Henriques, Tânia G. Lucas, Cláudio M. Gomes, (2016). Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders. Current Drug Targets, 17, 1527-1534. ISSN 1389-4501. eISSN . http://dx.doi.org/10.2174/1389450117666160813180812

IEEE
Bárbara J. Henriques, Tânia G. Lucas, Cláudio M. Gomes, "Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders" in Current Drug Targets, vol. 17, pp. 1527-1534, 2016. 10.2174/1389450117666160813180812

BIBTEX
@article{40963, author = {Bárbara J. Henriques and Tânia G. Lucas and Cláudio M. Gomes}, title = {Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders}, journal = {Current Drug Targets}, year = 2016, pages = {1527-1534}, volume = 17 }