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Publication details

Document type
Book chapters


Title
Chemical Approaches Towards Neurodegenerative Disease Prevention: The Role of Coupling Sugars to Phenolic Biomolecular Entities

Participants in the publication
Catarina Dias (Author)
Ana M. Matos (Author)
CQB - Centro de Química e Bioquímica 
Amélia P. Rauter (Author)
Dep. Química e Bioquímica
CQB - Centro de Química e Bioquímica 

Summary
Polyphenols are natural molecular entities exhibiting a wide variety of bioactivities including anticholinergic and/or antiamyloidogenic activities. Their low solubility is recognized as a key factor for bioavailability and their glycosylation is indeed relevant to improve the bioaccess to these molecules. In this chapter, chemical and enzymatic syntheses of glycosylated flavonoids, stilbenoids, phenylethanoids and phenylpropanoids are illustrated, covering examples that demonstrate the impact of coupling sugars to bioactive aglycones in their bioavailability and in their pharmacological activity. The chapter is focused particularly on glycosyl polyphenols with promising activities against neurodegenerative impairments, given their potential to intervene in biological processes that cause catastrophic diseases, namely the Alzheimer’s disease.

Editor(s)
Zbigniew J. Witczak, ‎Roman Bielski

Date of Publication
2018

Institution
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Where published
Coupling and Decoupling of Diverse Molecular Units in Glycosciences

Publication Identifiers
ISBN - 9783319655864,9783319655871

Publisher
Springer International Publishing

Edition
1st

Number of pages
27
Starting page
167
Last page
194

Document Identifiers
URL - http://dx.doi.org/10.1007/978-3-319-65587-1_8
DOI - https://doi.org/10.1007/978-3-319-65587-1_8

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APA
Catarina Dias, Ana M. Matos, Amélia P. Rauter, (2018). Chemical Approaches Towards Neurodegenerative Disease Prevention: The Role of Coupling Sugars to Phenolic Biomolecular Entities. Coupling and Decoupling of Diverse Molecular Units in Glycosciences, 167-194

IEEE
Catarina Dias, Ana M. Matos, Amélia P. Rauter, "Chemical Approaches Towards Neurodegenerative Disease Prevention: The Role of Coupling Sugars to Phenolic Biomolecular Entities" in Coupling and Decoupling of Diverse Molecular Units in Glycosciences, 2018, pp. 167-194

BIBTEX
@incollection{40206, author = {Catarina Dias and Ana M. Matos and Amélia P. Rauter}, title = {Chemical Approaches Towards Neurodegenerative Disease Prevention: The Role of Coupling Sugars to Phenolic Biomolecular Entities}, booktitle = {Coupling and Decoupling of Diverse Molecular Units in Glycosciences}, year = 2018, pages = {167-194}, address = {}, publisher = {Springer International Publishing} }