BIBLIOS

Tipo
Capítulo em Livro


Título
Chemical Approaches Towards Neurodegenerative Disease Prevention: The Role of Coupling Sugars to Phenolic Biomolecular Entities

Participantes na publicação
Catarina Dias (Author)
Ana M. Matos (Author)
CQB
Amélia P. Rauter (Author)
Dep. Química e Bioquímica
CQB

Resumo
Polyphenols are natural molecular entities exhibiting a wide variety of bioactivities including anticholinergic and/or antiamyloidogenic activities. Their low solubility is recognized as a key factor for bioavailability and their glycosylation is indeed relevant to improve the bioaccess to these molecules. In this chapter, chemical and enzymatic syntheses of glycosylated flavonoids, stilbenoids, phenylethanoids and phenylpropanoids are illustrated, covering examples that demonstrate the impact of coupling sugars to bioactive aglycones in their bioavailability and in their pharmacological activity. The chapter is focused particularly on glycosyl polyphenols with promising activities against neurodegenerative impairments, given their potential to intervene in biological processes that cause catastrophic diseases, namely the Alzheimer’s disease.

Editor
Zbigniew J. Witczak, ‎Roman Bielski


Instituição
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Suporte
Coupling and Decoupling of Diverse Molecular Units in Glycosciences

Identificadores da Publicação
ISBN - 9783319655864,9783319655871

Editora
Springer International Publishing



Identificadores do Documento
URL - http://dx.doi.org/10.1007/978-3-319-65587-1_8
DOI - https://doi.org/10.1007/978-3-319-65587-1_8

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