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Publication details

Document type
Book chapters


Title
Investigating Alternative Transport of Integral Plasma Membrane Proteins from the ER to the Golgi: Lessons from the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Participants in the publication
Margarida D. Amaral (Author)
Dep. Química e Bioquímica
BIOISI - Instituto de Biossistemas e Ciências Integrativas
Carlos M. Farinha (Author)
Dep. Química e Bioquímica
BIOISI - Instituto de Biossistemas e Ciências Integrativas
Paulo Matos (Author)
Hugo M. Botelho (Author)
BIOISI - Instituto de Biossistemas e Ciências Integrativas

Scope
International

Summary
Secretory traffic became a topical field because many important cell regulators are plasma membrane proteins (transporters, channels, receptors), being thus key targets in biomedicine and drug discovery. Cystic fibrosis (CF), caused by defects in a single gene encoding the CF transmembrane conductance regulator (CFTR), constitutes the most common of rare diseases and certainly a paradigmatic one.Here we focus on five different approaches that allow biochemical and cellular characterization of CFTR from its co-translational insertion into the ER membrane to its delivery to the plasma membrane.

Date of Publication
2016

Where published
Unconventional Protein Secretion,Methods in Molecular Biology

Publication Identifiers
ISSN - 1064-3745
ISBN - 9781493938025,9781493938049

Publisher
Springer New York

Edition
1st

Number of pages
21
Starting page
105
Last page
126

Document Identifiers
URL - http://dx.doi.org/10.1007/978-1-4939-3804-9_7
DOI - https://doi.org/10.1007/978-1-4939-3804-9_7

Rankings
SCIMAGO Q3 (2016) - 0.585 - Genetics

Keywords
Secretory traffic Biochemistry CFTR Cystic fibrosis Endoplasmic reticulum Golgi High-throughput microscopy Plasma membrane N-glycosylation ABC transporters


Export

APA
Margarida D. Amaral, Carlos M. Farinha, Paulo Matos, Hugo M. Botelho, (2016). Investigating Alternative Transport of Integral Plasma Membrane Proteins from the ER to the Golgi: Lessons from the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Unconventional Protein Secretion,Methods in Molecular Biology, 105-126

IEEE
Margarida D. Amaral, Carlos M. Farinha, Paulo Matos, Hugo M. Botelho, "Investigating Alternative Transport of Integral Plasma Membrane Proteins from the ER to the Golgi: Lessons from the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)" in Unconventional Protein Secretion,Methods in Molecular Biology, 2016, pp. 105-126

BIBTEX
@incollection{40034, author = {Margarida D. Amaral and Carlos M. Farinha and Paulo Matos and Hugo M. Botelho}, title = {Investigating Alternative Transport of Integral Plasma Membrane Proteins from the ER to the Golgi: Lessons from the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)}, booktitle = {Unconventional Protein Secretion,Methods in Molecular Biology}, year = 2016, pages = {105-126}, address = {}, publisher = {Springer New York} }