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Publication details

Document type
Journal articles

Document subtype
Full paper

Title
Antibiotic Resistance Gene Diversity and Virulence Gene Diversity Are Correlated in Human Gut and Environmental Microbiomes

Participants in the publication
Pedro Escudeiro (Author)
Joël Pothier (Author)
Francisco Dionisio (Author)
Dep. Biologia Vegetal
CE3C - Centro de Ecologia, Evolução e Alterações Ambientais
Teresa Nogueira (Author)

Scope
International

Refereeing
Yes

Summary
Human beings have used large amounts of antibiotics, not only in medical contexts but also, for example, as growth factors in agriculture and livestock, resulting in the contamination of the environment. Even when pathogenic bacteria are the targets of antibiotics, hundreds of nonpathogenic bacterial species are affected as well. Therefore, both pathogenic and nonpathogenic bacteria have gradually become resistant to antibiotics. We tested whether there is still cooccurrence of resistance and virulence determinants. We performed a comparative study of environmental and human gut metagenomes from different individuals and from distinct human populations across the world. We found a great diversity of antibiotic resistance determinants (AR diversity [ARd]) and virulence factors (VF diversity [VFd]) in metagenomes. Importantly there is a correlation between ARd and VFd, even after correcting for protein family richness. In the human gut, there are less ARd and VFd than in more diversified environments, and yet correlations between the ARd and VFd are stronger. They can vary from very high in Malawi, where antibiotic consumption is unattended, to nonexistent in the uncontacted Amerindian population. We conclude that there is cooccurrence of resistance and virulence determinants in human gut microbiomes, suggesting a possible coselective mechanism.

Date of Publication
2019-05-01

Institution
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Where published
mSphere

Publication Identifiers
ISSN - 2379-5042

Publisher
American Society for Microbiology

Volume
4
Number
3

Document Identifiers
URL - http://dx.doi.org/10.1128/msphere.00135-19
DOI - https://doi.org/10.1128/msphere.00135-19

Rankings
Web Of Science Q1 (2018) - 4.447 - MICROBIOLOGY - SCIE
SCIMAGO Q1 (2018) - 2.178 - Microbiology


Export

APA
Pedro Escudeiro, Joël Pothier, Francisco Dionisio, Teresa Nogueira, (2019). Antibiotic Resistance Gene Diversity and Virulence Gene Diversity Are Correlated in Human Gut and Environmental Microbiomes. mSphere, 4, ISSN 2379-5042. eISSN . http://dx.doi.org/10.1128/msphere.00135-19

IEEE
Pedro Escudeiro, Joël Pothier, Francisco Dionisio, Teresa Nogueira, "Antibiotic Resistance Gene Diversity and Virulence Gene Diversity Are Correlated in Human Gut and Environmental Microbiomes" in mSphere, vol. 4, 2019. 10.1128/msphere.00135-19

BIBTEX
@article{39322, author = {Pedro Escudeiro and Joël Pothier and Francisco Dionisio and Teresa Nogueira}, title = {Antibiotic Resistance Gene Diversity and Virulence Gene Diversity Are Correlated in Human Gut and Environmental Microbiomes}, journal = {mSphere}, year = 2019, volume = 4 }