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Detalhes Referência

Tipo
Artigos em Revista

Tipo de Documento
Artigo Completo

Título
Antibiotic Resistance Gene Diversity and Virulence Gene Diversity Are Correlated in Human Gut and Environmental Microbiomes

Participantes na publicação
Pedro Escudeiro (Author)
Joël Pothier (Author)
Francisco Dionisio (Author)
Dep. Biologia Vegetal
 cE3c
 Teresa Nogueira (Author)
cE3c/FCUL
Resumo
Human beings have used large amounts of antibiotics, not only in medical contexts but also, for example, as growth factors in agriculture and livestock, resulting in the contamination of the environment. Even when pathogenic bacteria are the targets of antibiotics, hundreds of nonpathogenic bacterial species are affected as well. Therefore, both pathogenic and nonpathogenic bacteria have gradually become resistant to antibiotics. We tested whether there is still cooccurrence of resistance and virulence determinants. We performed a comparative study of environmental and human gut metagenomes from different individuals and from distinct human populations across the world. We found a great diversity of antibiotic resistance determinants (AR diversity [ARd]) and virulence factors (VF diversity [VFd]) in metagenomes. Importantly there is a correlation between ARd and VFd, even after correcting for protein family richness. In the human gut, there are less ARd and VFd than in more diversified environments, and yet correlations between the ARd and VFd are stronger. They can vary from very high in Malawi, where antibiotic consumption is unattended, to nonexistent in the uncontacted Amerindian population. We conclude that there is cooccurrence of resistance and virulence determinants in human gut microbiomes, suggesting a possible coselective mechanism.

Data de Publicação
2019-05-01

Instituição
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Suporte
mSphere

Identificadores da Publicação
ISSN - 2379-5042

Editora
American Society for Microbiology

Volume
4
Fascículo
3

Identificadores do Documento
URL - http://dx.doi.org/10.1128/msphere.00135-19
DOI - https://doi.org/10.1128/msphere.00135-19

Identificadores de Qualidade
Web Of Science Q1 (2018) - 4.447 - MICROBIOLOGY - SCIE
SCIMAGO Q1 (2018) - 2.178 - Microbiology


Exportar referência

APA
Pedro Escudeiro, Joël Pothier, Francisco Dionisio, Teresa Nogueira, (2019). Antibiotic Resistance Gene Diversity and Virulence Gene Diversity Are Correlated in Human Gut and Environmental Microbiomes. mSphere, 4, ISSN 2379-5042. eISSN . http://dx.doi.org/10.1128/msphere.00135-19

IEEE
Pedro Escudeiro, Joël Pothier, Francisco Dionisio, Teresa Nogueira, "Antibiotic Resistance Gene Diversity and Virulence Gene Diversity Are Correlated in Human Gut and Environmental Microbiomes" in mSphere, vol. 4, 2019. 10.1128/msphere.00135-19

BIBTEX
@article{39322, author = {Pedro Escudeiro and Joël Pothier and Francisco Dionisio and Teresa Nogueira}, title = {Antibiotic Resistance Gene Diversity and Virulence Gene Diversity Are Correlated in Human Gut and Environmental Microbiomes}, journal = {mSphere}, year = 2019, volume = 4 }