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Publication details

Document type
Journal articles

Document subtype
Full paper

Title
Broad bean (Vicia faba L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties

Participants in the publication
Faiza Mejri (Author)
Slimen Selmi (Author)
Alice Martins (Author)
Haifa benkhoud (Author)
Tarek Baati (Author)
Hedia Chaabane (Author)
Leila Njim (Author)
Maria L. M. Serralheiro (Author)
Dep. Química e Bioquímica
BIOISI - Instituto de Biossistemas e Ciências Integrativas
Amélia P. Rauter (Author)
Dep. Química e Bioquímica
CQB - Centro de Química e Bioquímica 
Karim Hosni (Author)

Scope
International

Refereeing
Yes

Summary
This study was aimed at investigating the chemical composition (proximate, minerals, fatty acids and phenolic compounds) and the in vitro (antimicrobial, radical scavenging, anti-acetylcholinesterase and protein denaturing activities) and in vivo (anti-diabetic and histo-protective e?ects in alloxan-induced diabetic mice) biological activities of broad bean pods (BBPs), a food waste by-product material. The results showed that BBPs have high dietary ?ber (57.46%), carbohydrate (18.93%) and protein (13.81%) content versus low fat content (<1%) contributing to a low energy value of 139.24 kcal per 100 g. Pro?ling of fatty acids showed an abundance of the essential polyunsaturated α-linolenic and linoleic acids, exhibiting an excellent nutritional quality as revealed by their low atherogenic and thrombogenic indices and their hypocholesterolemic properties. The methanol extract which exhibited the highest total phenolic, ?avonoid and tannin contents was found to be the most active extract in terms of antimicrobial and antiradical activities. In alloxan-induced diabetic mice, the oral administration of a methanol extract (500 mg per kg bw) attenuated the elevated levels of serum alanine aminotransferase (ALA), aspartate aminotransferase (AST), and alkaline phosphatase activities, and urea, uric acid, and creatinine. It e?ectively normalized the status of lipid pro?les, mitigated oxidative stress through the activation of antioxidant enzymes (CAT, GPx and SOD), and alleviated oxidative stress-mediated histopathological changes in the pancreas, liver, kidney and testis. Compositional analysis by HPLC-PDA-ESI-MS/MS revealed the presence of ?avan-3-ols (catechin, epicatechin and their derivatives), ?avones (apigenin derivatives) and ?avonols (glycosides of quercetin and kaempferol), among others. These ?ndings suggest that BBPs may be an e?ective functional food for the management of diabetes and its complications.\\\\\\\\n

Date of Submisson/Request
2018-01-09
Date of Acceptance
2018-02-25
Date of Publication
2018-00-00

Institution
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Where published
Food & Function

Publication Identifiers
ISSN - 2042-6496

Publisher
Royal Society of Chemistry (RSC)

Volume
9
Number
4

Starting page
2051
Last page
2069

Document Identifiers
URL - http://dx.doi.org/10.1039/c8fo00055g
DOI - https://doi.org/10.1039/c8fo00055g

Rankings
Web Of Science Q1 (2018) - 3.241 - Food Science
SCIMAGO Q1 (2018) - 1 - Food Science
SCOPUS Q1 (2017) - 1.209 - Food Science

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APA
Faiza Mejri, Slimen Selmi, Alice Martins, Haifa benkhoud, Tarek Baati, Hedia Chaabane, Leila Njim, Maria L. M. Serralheiro, Amélia P. Rauter, Karim Hosni, (2018). Broad bean (Vicia faba L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties. Food & Function, 9, 2051-2069. ISSN 2042-6496. eISSN . http://dx.doi.org/10.1039/c8fo00055g

IEEE
Faiza Mejri, Slimen Selmi, Alice Martins, Haifa benkhoud, Tarek Baati, Hedia Chaabane, Leila Njim, Maria L. M. Serralheiro, Amélia P. Rauter, Karim Hosni, "Broad bean (Vicia faba L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties" in Food & Function, vol. 9, pp. 2051-2069, 2018. 10.1039/c8fo00055g

BIBTEX
@article{37770, author = {Faiza Mejri and Slimen Selmi and Alice Martins and Haifa benkhoud and Tarek Baati and Hedia Chaabane and Leila Njim and Maria L. M. Serralheiro and Amélia P. Rauter and Karim Hosni}, title = {Broad bean (Vicia faba L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties}, journal = {Food & Function}, year = 2018, pages = {2051-2069}, volume = 9 }