BIBLIOS

Tipo
Artigos em Revista

Tipo de Documento
Artigo Completo

Título
Broad bean (Vicia faba L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties

Participantes na publicação
Faiza Mejri (Author)
Slimen Selmi (Author)
Alice Martins (Author)
Haifa benkhoud (Author)
Tarek Baati (Author)
Hedia Chaabane (Author)
Leila Njim (Author)
Maria L. M. Serralheiro (Author)
Dep. Química e Bioquímica
BioISI
Amélia P. Rauter (Author)
Dep. Química e Bioquímica
CQB
Karim Hosni (Author)

Resumo
This study was aimed at investigating the chemical composition (proximate, minerals, fatty acids and phenolic compounds) and the in vitro (antimicrobial, radical scavenging, anti-acetylcholinesterase and protein denaturing activities) and in vivo (anti-diabetic and histo-protective e?ects in alloxan-induced diabetic mice) biological activities of broad bean pods (BBPs), a food waste by-product material. The results showed that BBPs have high dietary ?ber (57.46%), carbohydrate (18.93%) and protein (13.81%) content versus low fat content (<1%) contributing to a low energy value of 139.24 kcal per 100 g. Pro?ling of fatty acids showed an abundance of the essential polyunsaturated α-linolenic and linoleic acids, exhibiting an excellent nutritional quality as revealed by their low atherogenic and thrombogenic indices and their hypocholesterolemic properties. The methanol extract which exhibited the highest total phenolic, ?avonoid and tannin contents was found to be the most active extract in terms of antimicrobial and antiradical activities. In alloxan-induced diabetic mice, the oral administration of a methanol extract (500 mg per kg bw) attenuated the elevated levels of serum alanine aminotransferase (ALA), aspartate aminotransferase (AST), and alkaline phosphatase activities, and urea, uric acid, and creatinine. It e?ectively normalized the status of lipid pro?les, mitigated oxidative stress through the activation of antioxidant enzymes (CAT, GPx and SOD), and alleviated oxidative stress-mediated histopathological changes in the pancreas, liver, kidney and testis. Compositional analysis by HPLC-PDA-ESI-MS/MS revealed the presence of ?avan-3-ols (catechin, epicatechin and their derivatives), ?avones (apigenin derivatives) and ?avonols (glycosides of quercetin and kaempferol), among others. These ?ndings suggest that BBPs may be an e?ective functional food for the management of diabetes and its complications.\\\\\\\\n


Instituição
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Suporte
Food & Function

Identificadores da Publicação
ISSN - 2042-6496

Editora
Royal Society of Chemistry (RSC)



Identificadores do Documento
URL - http://dx.doi.org/10.1039/c8fo00055g
DOI - https://doi.org/10.1039/c8fo00055g

Identificadores de Qualidade
Web Of Science Q1 (2018) - 3.241 - Food Science
SCIMAGO Q1 (2018) - 1 - Food Science
SCOPUS Q1 (2017) - 1.209 - Food Science

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