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Publication details

Document type
Patents


Title
M13 bacteriophages displaying peptide motifs targeting amyloid-βeta, methods and uses thereof

Participants in the publication
Ivone Martins (Author)
UNIVERSIDADE DO MINHO
 Helmut Kessels (Author)
Joana Azeredo (Author)
UNIVERSIDADE DO MINHO
 Cláudio M. Gomes (Author)
Dep. Química e Bioquímica
 BioISI
 Joana S. Cristóvão (Author)
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA
 BioISI - Biosystems & Integrative Sciences Institute
Summary
The present disclosure relates to a M13 bacteriophage (phage for short), displaying amyloidogenic peptide motifs from amyloid beta 42 (Aβ42) at its surface. The present disclosure further relates to the use of the disclosed engineered M13 bacteriophage for detecting early species of Aβ, namely soluble oligomeric and fibrillar Aβ, and preventing and/or inhibiting its aggregation promoting the inhibition of the progression of Alzheimer´s disease (AD) and thus contributing to the treatment of this neurodegenerative disorder.

Date of Submisson/Request
2022-08-12

Publication Identifiers

Notes
PINPI number: PT118159



Export

APA
Ivone Martins, Helmut Kessels, Joana Azeredo, Cláudio M. Gomes, Joana S. Cristóvão, (). M13 bacteriophages displaying peptide motifs targeting amyloid-βeta, methods and uses thereof

IEEE
Ivone Martins, Helmut Kessels, Joana Azeredo, Cláudio M. Gomes, Joana S. Cristóvão, "M13 bacteriophages displaying peptide motifs targeting amyloid-βeta, methods and uses thereof",

BIBTEX
@misc{64998, author = {Ivone Martins and Helmut Kessels and Joana Azeredo and Cláudio M. Gomes and Joana S. Cristóvão}, title = {M13 bacteriophages displaying peptide motifs targeting amyloid-βeta, methods and uses thereof}, year = }