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Publication details

Document type
Patents


Title
M13 bacteriophages displaying peptide motifs targeting amyloid- eta, methods and uses thereof

Participants in the publication
Ivone M. Martins (Author)
UNIVERSIDADE DO MINHO
 Joana Azeredo (Author)
UNIVERSIDADE DO MINHO
 Helmut W. Kessels (Author)
Cláudio M. Gomes (Author)
Dep. Química e Bioquímica
 BioISI
 Joana S. Cristóvão (Author)
BioISI - Biosystems & Integrative Sciences Institute
 FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA
Summary
The present disclosure relates to an engineered M13 bacteriophage displaying amyloidogenic peptide motifs from amyloid beta 42 (A42) at its surface. The present disclosure further relates to the use of the disclosed engineered M13 bacteriophage for detecting early species of A, namely oligomeric and fibrillar A, and preventing its aggregation promoting the inhibition of the progression of Alzheimer's disease and thus contributing to the treatment of this neurodegenerative disorder.

Date of Submisson/Request
2023-08-14
Data de Concessão
2024-02-15

Publication Identifiers

Notes
International Patent: WO/2024/033903


Export

APA
Ivone M. Martins, Joana Azeredo, Helmut W. Kessels, Cláudio M. Gomes, Joana S. Cristóvão, (2024). M13 bacteriophages displaying peptide motifs targeting amyloid- eta, methods and uses thereof

IEEE
Ivone M. Martins, Joana Azeredo, Helmut W. Kessels, Cláudio M. Gomes, Joana S. Cristóvão, "M13 bacteriophages displaying peptide motifs targeting amyloid- eta, methods and uses thereof", 2024

BIBTEX
@misc{64995, author = {Ivone M. Martins and Joana Azeredo and Helmut W. Kessels and Cláudio M. Gomes and Joana S. Cristóvão}, title = {M13 bacteriophages displaying peptide motifs targeting amyloid- eta, methods and uses thereof}, year = 2024 }