Tipo
Outros
Tipo de Documento
Sumários executivos
Título
Alternative therapeutic strategies to the treatment of drug-refractory temporal lobe epilepsy
Participantes na publicação
D Cunha-Reis (Author)
Dep. Biologia Vegetal
BioISI
Resumo
This project proposes to evaluate the therapeutic potential of three different strategies for mesial temporal-lobe epilepsy with hippocampal sclerosis (MTLE-HS). These three distinct approaches are aimed at to two specific aspects of disease pathology: 1) altered hippocampal synaptic plasticity mechanisms and 2) hippocampal GABAergic interneuron survival/adaptation, which is dependent on the activity of extrinsic projections to these interneurons. Vasoactive intestinal peptide (VIP) VPAC1 receptor ligands will be used to target early synaptic plasticity changes leading to epileptogenesis and contributing to selective interneuron death. Mismatch novelty training will be used to rescue altered synaptic plasticity in the chronic phase of MTLE and rescue median raphe serotonergic and septal GABAergic extrinsic innervation of the hippocampus. MTLE impact on membrane lipid composition, synaptic lipid raft dynamics, and consequences for synaptic plasticity aims to determine if synapses and neuronal membranes are important therapeutic targets of ketogenic diet therapy.
Data de Publicação
2019-07-01
Identificadores da Publicação
Editora
Fundacao para a Ciencia e a Tecnologia (unidadeFCCN)
Identificadores do Documento
DOI -
https://doi.org/10.54499/dl57/2016/cp1479/ct0044
URL -
http://dx.doi.org/10.54499/dl57/2016/cp1479/ct0044