BIBLIOS

Tipo
Artigos em Revista

Tipo de Documento
Artigo Completo

Título
Radiation as a Tool against Neurodegeneration—A Potential Treatment for Amyloidosis in the Central Nervous System

Participantes na publicação
Carina Marques Coelho (Author)
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA
LABORATÓRIO DE INSTRUMENTAÇÃO E FÍSICA EXPERIMENTAL DE PARTÍCULAS
Lia Pereira (Author)
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA
LABORATÓRIO DE INSTRUMENTAÇÃO E FÍSICA EXPERIMENTAL DE PARTÍCULAS
Pamela Teubig (Author)
Dep. Física
CFNUL
LIP
Pedro Santos (Author)
Filipa Mendes (Author)
Sílvia Viñals (Co-Supervisor)
Daniel Galaviz (Co-Supervisor)
Dep. Física
Dep. Física
CFNUL
LIP
Federico Herrera (Supervisor)
Dep. Química e Bioquímica
BioISI

Resumo
Radiotherapy (RT) is a relatively safe and established treatment for cancer, where the goal is to kill tumoral cells with the lowest toxicity to healthy tissues. Using it for disorders involving cell loss is counterintuitive. However, ionizing radiation has a hormetic nature: it can have deleterious or beneficial effects depending on how it is applied. Current evidence indicates that radiation could be a promising treatment for neurodegenerative disorders involving protein misfolding and amyloidogenesis, such as Alzheimer's or Parkinson's diseases. Low-dose RT can trigger antioxidant, anti-inflammatory and tissue regeneration responses. RT has been used to treat peripheral amyloidosis, which is very similar to other neurodegenerative disorders from a molecular perspective. Ionizing radiation prevents amyloid formation and other hallmarks in cell cultures, animal models and pilot clinical trials. Although some hypotheses have been formulated, the mechanism of action of RT on systemic amyloid deposits is still unclear, and uncertainty remains regarding its impact in the central nervous system. However, new RT modalities such as low-dose RT, FLASH, proton therapy or nanoparticle-enhanced RT could increase biological effects while reducing toxicity. Current evidence indicates that the potential of RT to treat neurodegeneration should be further explored.


Instituição
BioISI - Biosystems & Integrative Sciences Institute

Suporte
International Journal of Molecular Sciences

Identificadores da Publicação
ISSN - 1422-0067

Editora
MDPI AG



Identificadores do Documento
DOI - https://doi.org/10.3390/ijms232012265
URL - http://dx.doi.org/10.3390/ijms232012265

Identificadores de Qualidade
SCIMAGO Q1 (2018) - 1.312 - Medicine (miscellaneous)
SCIMAGO Q1 (2018) - 1.312 - Organic Chemistry
SCOPUS Q2 (2019) - 5.3 - Molecular Biology

Keywords
Neurodegenerative disorders amyloid radiotherapy

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