Document type
Journal articles
Document subtype
Full paper
Title
A Comprehensive Updated Review on Magnetic Nanoparticles in Diagnostics
Participants in the publication
Pedro Farinha (Author)
João M. P. Coelho (Author)
Dep. Física
IBEB
Catarina Pinto Reis (Author)
Maria Manuela Gaspar (Author)
Summary
Magnetic nanoparticles (MNPs) have been studied for diagnostic purposes for decades. Their high surface-to-volume ratio, dispersibility, ability to interact with various molecules and superparamagnetic properties are at the core of what makes MNPs so promising. They have been applied in a multitude of areas in medicine, particularly Magnetic Resonance Imaging (MRI). Iron oxide nanoparticles (IONPs) are the most well-accepted based on their excellent superparamagnetic properties and low toxicity. Nevertheless, IONPs are facing many challenges that make their entry into the market difficult. To overcome these challenges, research has focused on developing MNPs with better safety profiles and enhanced magnetic properties. One particularly important strategy includes doping MNPs (particularly IONPs) with other metallic elements, such as cobalt (Co) and manganese (Mn), to reduce the iron (Fe) content released into the body resulting in the creation of multimodal nanoparticles with unique properties. Another approach includes the development of MNPs using other metals besides Fe, that possess great magnetic or other imaging properties. The future of this field seems to be the production of MNPs which can be used as multipurpose platforms that can combine different uses of MRI or different imaging techniques to design more effective and complete diagnostic tests.
Date of Publication
2021-12-17
Where published
Nanomaterials
Publication Identifiers
ISSN - 2079-4991
Publisher
MDPI AG
Document Identifiers
DOI -
https://doi.org/10.3390/nano11123432
URL -
http://dx.doi.org/10.3390/nano11123432
Rankings
SCIMAGO Q1 (2020) - 0.92 - Chemical Engineering Chemical Engineering (miscellaneous)