BIBLIOS

Document type
Journal articles

Document subtype
Full paper

Title
Heteroleptic enantiopure Pd(ii)-complexes derived from halogen-substituted Schiff bases and 2-picolylamine: synthesis, experimental and computational characterization and investigation of the influence of chirality and halogen atoms on the anticancer activity

Participants in the publication
Hadi Amiri Rudbari (Author)
Nazanin Kordestani (Author)
Isabel Correia (Author)
INSTITUTO SUPERIOR TÉCNICO
Andreia Valente (Author)
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA
CQE
Leonor Côrte-Real (Author)
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA
CQE
Mohammad Khairul Islam (Author)
Nicola Micale (Author)
Jason D. Braun (Author)
David E. Herbert (Author)
Nikolay Tumanov (Author)
Johan Wouters (Author)
Mohammed Enamullah (Author)

Summary
Seven enantiomeric pairs of palladium complexes, [Pd(pic)(R or S)-N-1-(phenyl)ethyl-2,4-X1,X2-salicylaldiminate)]NO3, [Pd(pic)(R or S)]NO3 (X1 = X2 = Cl, Br, I, H; X1/X2 = Br/Cl), were synthesized by the reaction of enantiopure halogen-substituted Schiff bases (R or S)-N-1-(phenyl)ethyl-2,4-X1,X2-salicylaldimine with [Pd(pic)Cl2] (pic = 2-picolylamine). The composition and structure of the complexes were confirmed by means of FT-IR, 1H NMR and 13C NMR spectroscopy, elemental analysis and X-ray crystallography. The electronic structure of the reported complexes was investigated using UV–vis absorption and electronic circular dichroism (ECD) spectroscopy, complemented by DFT/TDDFT modelling. To investigate the effect of chirality and different halogen substituents on the anticancer activity of the complexes, the cytotoxic activity of all fourteen complexes was tested in the human breast cancer cell lines MDA-MB-231 and MCF-7 at 24 h using the colorimetric MTT assay. Also, the cell death mechanism was assessed using the annexin V/propidium iodide (AV/PI) cytometry-based assay.


Where published
New Journal of Chemistry

Publication Identifiers
ISSN - 1144-0546

Publisher
Royal Society of Chemistry (RSC)



Document Identifiers
DOI - https://doi.org/10.1039/d1nj01491a
URL - http://dx.doi.org/10.1039/d1nj01491a

Rankings
SCIMAGO Q1 (2021) - 0.693 - Materials Chemistry