BIBLIOS

Tipo
Artigos em Revista

Tipo de Documento
Artigo Completo

Título
Acidity and Hydrophobicity of Several New Potential Antitubercular Drugs: Isoniazid and Benzimidazole Derivatives

Participantes na publicação
Clara Ràfols (Author)
Elisabeth Bosch (Author)
Rebeca Ruiz (Author)
Karl J. Box (Author)
Marina Reis (Author)
Cristina Ventura (Author)
Susana Santos (Author)
M. Eduarda Araújo (Author)
Filomena Martins (Author)
Dep. Química e Bioquímica
CQB

Resumo
Hydrophobicity values (log Po/w) determined both by potentiometry and by the conventional shake-flask method and aqueous pKa values obtained by potentiometry for seven isoniazid and nine benzimidazole derivatives are presented. Several of these compounds have strong hydrophilic or hydrophobic character, and some of them show two or more ionizable sites, sometimes very acidic or very basic. These facts have compelled us to work near the limits of the potentiometric technique, and therefore, a critical evaluation of the results obtained in these extreme working conditions is presented. Particularly, details about the potentiometric determination of log Po/w values of the most hydrophilic and most hydrophobic compounds are clearly described.


Instituição
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Suporte
Journal of Chemical & Engineering Data

Identificadores da Publicação

Editora
American Chemical Society (ACS)



Identificadores do Documento
DOI - https://doi.org/10.1021/je200827u
URL - http://dx.doi.org/10.1021/je200827u

Identificadores de Qualidade
SCIMAGO Q1 (2012) - 1.139 - Chemistry (miscellaneous)
Web Of Science Q2 (2012) - 2.004 - Chemical, mutidisciplinary