BIBLIOS

Document type
Book chapters


Title
Chapter 6 – New Inorganic Therapeutics I “Ruthenium and iron metallodrugs: new inorganic and organometallic complexes as prospective anticancer agents” in Synthetic Inorganic Chemistry – New perspectives

Participants in the publication
Andreia Valente (Author)
Dep. Química e Bioquímica
CQE
Tânia S. Morais (Author)
Dep. Química e Bioquímica
Dep. Química e Bioquímica
CQE
Ricardo G. Teixeira (Author)
Cristina P. Matos (Author)
M. Helena Garcia (Author)
Dep. Química e Bioquímica
CQE
Ana Isabel Tomaz (Author)
Dep. Química e Bioquímica
CQE

Summary
"Synthetic Inorganic Chemistry: New Perspectives" presents summaries of the work of some of the most creative researchers in the field. The book highlights the most novel approaches and burgeoning applications of synthetic inorganic chemistry in development. As the first volume in the Developments in Inorganic Chemistry series, this work is a valuable resource for students and researchers working in inorganic chemistry and material science.In this Chapter (6 - New Inorganic therapeutics, I) we address the development of ruthenium- and iron-based metallodrugs as prospective chemotherapeutics in cancer treatment. We provide an overview of the field addressing iron and ruthenium complexes reported as promising anti-cancer metallodrug candidates, on their properties and specific features, and mostly focus on newer contributions in this field which include ‘classical’ coordination complexes and organometallic compounds. The first group comprises Fe(III) and Ru(III) complexes with octahedral geometry and a tetradentate ligand, namely ternary tripodal aminobisphenolates and cyclam derivatives for Fe(III) or salen- and salan-like ligands for Ru(III). In the larger group of organometallic complexes, we highlight the value of the M(Cp) scaffold in metallodrug design (M being Ru(II) and Fe(II), Cp being eta5-cyclopentadienyl) and provide examples of very effective compounds with modes of action that are distinct from those of Pt-based drugs in clinical use, including some Ru(Cp) complexes with ability to overcome multidrug resistance mechanisms.

Editor(s)
Ewan J. M. Hamilton


Institution
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Where published
Elsevier

Publication Identifiers
ISBN - [eBook ISBN]: 9780128189337

Publisher
Elsevier Inc.



Document Identifiers
DOI - https://doi.org/10.1016/B978-0-12-818429-5.00010-7
ISBN - 9780128184295
URL - https://www.elsevier.com/books/synthetic-inorganic-chemistry/hamilton/978-0-12-818429-5

Notes
AIT: submitting author; corresponding author