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Publication details

Document type
Journal articles

Document subtype
Full paper

Title
Negative affect and stress-related brain metabolism in patients with metastatic breast cancer

Participants in the publication
Joaquim C. Reis (Author)
Luzia Travado (Author)
Michael H. Antoni (Author)
Francisco P. M. Oliveira (Author)
Silvia D. Almeida (Author)
Pedro Almeida (Author)
Dep. Física
IBEB - Instituto de Biofísica e Engenharia Biomédica
Aaron S. Heller (Author)
Berta Sousa (Author)
Durval C. Costa (Author)

Scope
International

Refereeing
Yes

Summary
BACKGROUND: Cancer and its treatment represent major stressors requiring that patients make multiple adaptations. Despite evidence that poor adaptation to stressors is associated with more distress and negative affect (NA), neuroimmune dysregulation and poorer health outcomes, current understanding is very limited of how NA covaries with central nervous system changes to account for these associations. METHODS: NA was correlated with brain metabolic activity using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in several regions of interest in 61 women with metastatic breast cancer. Patients underwent 18F-FDG PET/CT and completed an assessment of NA using the Brief Symptom Inventory. RESULTS: Regression analyses revealed that NA was significantly negatively correlated with the standardized uptake value ratio of the insula, thalamus, hypothalamus, ventromedial prefrontal cortex, and lateral prefrontal cortex. Voxel-wise correlation analyses within these 5 regions of interest demonstrated high left-right symmetry and the highest NA correlations with the anterior insula, thalamus (medial and ventral portion), lateral prefrontal cortex (right Brodmann area 9 [BA9], left BA45, and right and left BA10 and BA8), and ventromedial prefrontal cortex (bilateral BA11). CONCLUSIONS: The regions of interest most strongly negatively associated with NA represent key areas for successful adaptation to stressors and may be particularly relevant in patients with metastatic breast cancer who are dealing with multiple challenges of cancer and its treatment.

Date of Publication
2020-04-14

Institution
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Where published
Cancer

Publication Identifiers
ISSN - 0008-543X

Publisher
Wiley

Document Identifiers
DOI - https://doi.org/10.1002/cncr.32902
URL - http://dx.doi.org/10.1002/cncr.32902

Rankings
SCIMAGO Q1 (2018) - 3,489 - Cancer Research

Keywords
distress metastatic breast cancer; negative affect stress-related brain metabolism.


Export

APA
Joaquim C. Reis, Luzia Travado, Michael H. Antoni, Francisco P. M. Oliveira, Silvia D. Almeida, Pedro Almeida, Aaron S. Heller, Berta Sousa, Durval C. Costa, (2020). Negative affect and stress-related brain metabolism in patients with metastatic breast cancer. Cancer, ISSN 0008-543X. eISSN . http://dx.doi.org/10.1002/cncr.32902

IEEE
Joaquim C. Reis, Luzia Travado, Michael H. Antoni, Francisco P. M. Oliveira, Silvia D. Almeida, Pedro Almeida, Aaron S. Heller, Berta Sousa, Durval C. Costa, "Negative affect and stress-related brain metabolism in patients with metastatic breast cancer" in Cancer, 2020. 10.1002/cncr.32902

BIBTEX
@article{44088, author = {Joaquim C. Reis and Luzia Travado and Michael H. Antoni and Francisco P. M. Oliveira and Silvia D. Almeida and Pedro Almeida and Aaron S. Heller and Berta Sousa and Durval C. Costa}, title = {Negative affect and stress-related brain metabolism in patients with metastatic breast cancer}, journal = {Cancer}, year = 2020, }