BIBLIOS

  Ciências References Management System

Visitor Mode (Login)
Need help?


Back

Publication details

Document type
Journal articles

Document subtype
Full paper

Title
Metallothioneins in Prion- and Amyloid-Related Diseases

Participants in the publication
Pavlína Adam (Author)
So?a K?ížková (Author)
Zbyn?k Heger (Author)
Petr Babula (Author)
Vladimír Peka?ík (Author)
Markéta Vaculovi?oá (Author)
Cláudio M. Gomes (Author)
Dep. Química e Bioquímica
BIOISI - Instituto de Biossistemas e Ciências Integrativas
René Kizek (Author)
Vojt?ch Adam (Author)

Scope
International

Refereeing
Yes

Summary
Prion and other amyloid-forming diseases represent a group of neurodegenerative disorders that affect both animals and humans. The role of metal ions, especially copper and zinc is studied intensively in connection with these diseases. Their involvement in protein misfolding and aggregation and their role in creation of reactive oxygen species have been shown. Recent data also show that metal ions not only bind the proteins with high affinity, but also modify their biochemical properties, making them important players in prion-related diseases. In particular, the level of zinc ions is tightly regulated by several mechanisms, including transporter proteins and the low molecular mass thiol-rich metallothioneins. From four metallothionein isoforms, metallothionein-3, a unique brain-specific metalloprotein, plays a crucial role only in this regulation. This review critically evaluates the involvement of metallothioneins in prion- and amyloid-related diseases in connection with the relationship between metallothionein isoforms and metal ion regulation of their homeostasis.

Date of Publication
2016-03-30

Where published
Journal of Alzheimer's Disease

Publication Identifiers
ISSN - 1387-2877

Publisher
IOS Press

Volume
51
Number
3

Number of pages
19
Starting page
637
Last page
656

Document Identifiers
DOI - https://doi.org/10.3233/jad-150984
URL - http://dx.doi.org/10.3233/jad-150984

Rankings
SCIMAGO Q1 (2016) - 1.584 - Medicine (miscellaneous)
SCIMAGO Q1 (2017) - 1.635 - Neuroscience (miscellaneous)

Keywords
Alzheimer’s disease brain copper metallothionein nneurodegenerative disorders prion protein


Export

APA
Pavlína Adam, So?a K?ížková, Zbyn?k Heger, Petr Babula, Vladimír Peka?ík, Markéta Vaculovi?oá, Cláudio M. Gomes, René Kizek, Vojt?ch Adam, (2016). Metallothioneins in Prion- and Amyloid-Related Diseases. Journal of Alzheimer's Disease, 51, 637-656. ISSN 1387-2877. eISSN . http://dx.doi.org/10.3233/jad-150984

IEEE
Pavlína Adam, So?a K?ížková, Zbyn?k Heger, Petr Babula, Vladimír Peka?ík, Markéta Vaculovi?oá, Cláudio M. Gomes, René Kizek, Vojt?ch Adam, "Metallothioneins in Prion- and Amyloid-Related Diseases" in Journal of Alzheimer's Disease, vol. 51, pp. 637-656, 2016. 10.3233/jad-150984

BIBTEX
@article{41708, author = {Pavlína Adam and So?a K?ížková and Zbyn?k Heger and Petr Babula and Vladimír Peka?ík and Markéta Vaculovi?oá and Cláudio M. Gomes and René Kizek and Vojt?ch Adam}, title = {Metallothioneins in Prion- and Amyloid-Related Diseases}, journal = {Journal of Alzheimer's Disease}, year = 2016, pages = {637-656}, volume = 51 }