BIBLIOS

Tipo
Artigos em Revista

Tipo de Documento
Artigo Completo

Título
Exploring Anti-Prion Glyco-Based and Aromatic Scaffolds: A Chemical Strategy for the Quality of Life

Participantes na publicação
M. T. Blazquez-Sanchez (Author)
CQB
A. M. de Matos (Author)
CQB
A. P. Rauter (Author)
Dep. Química e Bioquímica
CQB

Resumo
Prion diseases are fatal neurodegenerative disorders caused by protein misfolding and aggregation, affecting the brain progressively and consequently the quality of life. Alzheimer’s is also a protein misfolding disease, causing dementia in over 40 million people worldwide. There are no therapeutics able to cure these diseases. Cellular prion protein is a high-affinity binding partner of amyloid β (Aβ) oligomers, the most toxic species in Alzheimer’s pathology. These findings motivate the development of new chemicals for a better understanding of the events involved. Disease control is far from being reached by the presently known therapeutics. In this review we describe the synthesis and mode of action of molecular entities with intervention in prion diseases’ biological processes and, if known, their role in Alzheimer’s. A diversity of structures is covered, based on glycans, steroids and terpenes, heterocycles, polyphenols, most of them embodying aromatics and a structural complexity. These molecules may be regarded as chemical tools to foster the understanding of the complex mechanisms involved, and to encourage the scientific community towards further developments for the cure of these devastating diseases.


Instituição
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Suporte
Molecules

Identificadores da Publicação
ISSN - 14203049

Editora
MDPI



Identificadores do Documento
DOI - http://dx.doi.org/10.3390/molecules22060864
DOI - https://doi.org/10.3390/molecules22060864

Identificadores de Qualidade
SCIMAGO Q1 (2017) - 0,855 - Chemistry (miscellaneous)

Keywords
structure optimization anti-prion compounds amyloid protein aggregation Prion

Anotações
This paper covers synthesis and mode of action of molecular entities with intervention in prion diseases’ biological
processes and, if known, their role in Alzheimer’s. A diversity of structures is presented, based on
glycans, steroids and terpenes, heterocycles, polyphenols, most of them embodying aromatics and a
structural complexity. These molecules may be regarded as chemical tools to foster the understanding
of the complex mechanisms involved, and to encourage the scientific community towards further
developments for the cure of these devastating diseases. I was the corresponding author of this paper.

Download