BIBLIOS

Document type
Journal articles

Document subtype
Full paper

Title
Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential

Participants in the publication
Ana Marta de Matos (Author)
CQB
Maria Paula de Macedo (Author)
Amélia Pilar Rauter (Author)
Dep. Química e Bioquímica
CQB

Summary
Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are two age-related amyloid diseasesthat affect millions of people worldwide. Broadly supported by epidemiological data, the higher inci-dence of AD among type 2 diabetic patients led to the recognition of T2D as a tangible risk factorfor the development of AD. Indeed, there is now growing evidence on brain structural and functionalabnormalities arising from brain insulin resistance and deficiency, ultimately highlighting the need fornew approaches capable of preventing the development of AD in type 2 diabetic patients. This reviewprovides an update on overlapping pathophysiological mechanisms and pathways in T2D and AD, suchas amyloidogenic events, oxidative stress, endothelial dysfunction, aberrant enzymatic activity, and evenshared genetic background. These events will be presented as puzzle pieces put together, thus establishingpotential therapeutic targets for drug discovery and development against T2D and diabetes-induced cog-nitive decline—a heavyweight contributor to the increasing incidence of dementia in developed countries.Hoping to pave the way in this direction, we will present some of the most promising and well-studied drugleads with potential against both pathologies, including their respective bioactivity reports, mechanismsof action, and structure–activity relationships.


Institution
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Where published
Medicinal Research Reviews

Publication Identifiers
ISSN - 0198-6325

Publisher
Wiley



Document Identifiers
URL - http://dx.doi.org/10.1002/med.21440
DOI - https://doi.org/10.1002/med.21440

Awards
THis Journal is ranked in the TOP 5% (1/61) in Medicinal Chemistry (ISIWEB)
This journal is ranked in the TOP 3% in Drug Discovery (SCIMAGO)

Rankings
SCIMAGO Q1 (2018) - 2,53 - Drug Discovery
Web Of Science Q1 (2018) - 9.791 - Chemistry, Medicinal

Keywords
diabetes-induced dementia natural products Alzheimer's disease drug design type 2 diabetes

Tags
JOURNAL RANKED TOP 5% (2/61 Medicinal Chemistry) ISIWEB Journal ranked TOP 3% (5/167 Drug Discovery) SCIMAGO

Notes
Corresponding author

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