BIBLIOS

  Ciências References Management System

Visitor Mode (Login)
Need help?


Back

Publication details

Document type
Journal articles

Document subtype
Full paper

Title
Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor

Participants in the publication
Marta Vieira (Author)
Sónia S. Leal (Author)
Cláudio M. Gomes (Author)
Dep. Química e Bioquímica
BIOISI - Instituto de Biossistemas e Ciências Integrativas
Maria João Saraiva (Author)

Scope
International

Refereeing
Yes

Summary
Transthyretin (TTR) has a neuroprotective role in the central nervous system (CNS) in Alzheimer's disease (AD) and cerebral ischemia. Increased levels of TTR and activated insulin-like growth factor I receptor (IGF-IR) are associated with reduced neurodegeneration in an AD mouse model. In the present study, we found that TTR and IGF-I have a synergistic effect on activation of one of the IGF-IR signaling pathways. Hippocampus of TTR null mice present decreased levels of phosphorylated IGF-IR and Akt when compared with TTR wild type littermate animals. Cell studies reveal the synergistic effect of TTR and IGF-I in promoting IGF-IR signaling even under glutamate induced toxicity. TTR:IGF-IR complexes are identified and a bio-layer interferometry assay demonstrated an interaction between TTR and IGF-IR with a KD ranging from 99 to 744nM. In summary, our results point to a new TTR role through the IGF-I axis, mediated through TTR-IGF-IR interactions.

Date of Publication
2016-04-00

Institution
BioISI - Biosystems & Integrative Sciences Institute

Where published
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Publication Identifiers
ISSN - 0925-4439

Publisher
Elsevier BV

Volume
1862
Number
4

Starting page
797
Last page
804

Document Identifiers
DOI - https://doi.org/10.1016/j.bbadis.2016.01.008
URL - http://dx.doi.org/10.1016/j.bbadis.2016.01.008

Rankings
SCIMAGO Q1 (2016) - 2.593 - Molecular Medicine
Web Of Science Q1 (2017) - 5.108 - BIOCHEMISTRY & MOLECULAR BIOLOGY - SCIE
SCOPUS Q1 (2015) - 2.8 - Molecular Medicine

Keywords
Glutamate Ischemia Protein–protein interaction


Export

APA
Marta Vieira, Sónia S. Leal, Cláudio M. Gomes, Maria João Saraiva, (2016). Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862, 797-804. ISSN 0925-4439. eISSN . http://dx.doi.org/10.1016/j.bbadis.2016.01.008

IEEE
Marta Vieira, Sónia S. Leal, Cláudio M. Gomes, Maria João Saraiva, "Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor" in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1862, pp. 797-804, 2016. 10.1016/j.bbadis.2016.01.008

BIBTEX
@article{38782, author = {Marta Vieira and Sónia S. Leal and Cláudio M. Gomes and Maria João Saraiva}, title = {Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor}, journal = {Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease}, year = 2016, pages = {797-804}, volume = 1862 }