BIBLIOS

  Ciências References Management System

Visitor Mode (Login)
Need help?


Back

Publication details

Document type
Journal articles

Document subtype
Full paper

Title
Unlocking the in vitro anti-inflammatory and antidiabetic potential of Polygonum maritimum

Participants in the publication
Maria João Rodrigues (Author)
Luísa Custódio (Author)
Andreia Lopes (Author)
Marta Oliveira (Author)
Nuno R. Neng (Author)
Dep. Química e Bioquímica
Dep. Química e Bioquímica
CQB - Centro de Química e Bioquímica 
José M. F. Nogueira (Author)
Dep. Química e Bioquímica
CQB - Centro de Química e Bioquímica 
Alice Martins (Author)
Amélia P. Rauter (Author)
Dep. Química e Bioquímica
CQB - Centro de Química e Bioquímica 
João Varela (Author)
Luísa Barreira (Author)

Scope
International

Refereeing
Yes

Summary
Context: Several Polygonum species (Polygonaceae) are used in traditional medicine in Asia, Europe and Africa to treat inflammation and diabetes. Objective: Evaluate the in vitro antioxidant, anti-inflammatory and antidiabetic potential of methanol and dichloromethane extracts of leaves and roots of the halophyte Polygonum maritimum L.\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nMaterial and methods: Antioxidant activity was determined (up to 1 mg/mL) as radical-scavenging activity (RSA) of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,20-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\n(ABTS), copper (CCA) and iron (ICA) chelating activities and iron reducing power (FRAP). NO production\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nwas measured in lipopolysaccharide (LPS)-stimulated macrophages for 24 h at concentrations up to\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\n100 lg/mL and antidiabetic potential was assessed by a-amylase and a-glucosidase inhibition (up to\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\n10 mg/mL) assays. The phytochemical composition of the extracts was determined by gas chromatography-mass spectrometry (GC-MS).\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nResults: The methanol leaf extract had the highest activity against DPPH· (IC50 ¼ 26 lg/mL) and ABTS1·\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\n(IC50 ¼ 140 lg/mL), FRAP (IC50 ¼ 48 lg/mL) and CCA (IC50 ¼ 770 lg/mL). Only the dichloromethane leaf\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nextract (LDCM) showed anti-inflammatory activity (IC50 ¼ 48 lg/mL). The methanol root (IC50 ¼ 19 lg/mL)\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nand leaf (IC50 ¼ 29 lg/mL) extracts strongly inhibited baker’s yeast a-glucosidase, but LDCM had higher\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nrat’s a-glucosidase inhibition (IC50 ¼ 2527 lg/mL) than acarbose (IC50 ¼ 4638 lg/mL). GC-MS analysis identified b-sitosterol, stigmasterol, 1-octacosanol and linolenic acid as possible molecules responsible for the\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nobserved bioactivities.\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nConclusions: Our findings suggest P. maritimum as a source of high-value health promoting commodities\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nfor alleviating symptoms associated with oxidative and inflammatory diseases, including diabetes.

Date of Publication
2017-01-00

Institution
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Where published
Pharmaceutical Biology

Publication Identifiers
ISSN - 1388-0209

Publisher
Informa UK Limited

Volume
55
Number
1

Starting page
1348
Last page
1357

Document Identifiers
DOI - https://doi.org/10.1080/13880209.2017.1301493
URL - http://dx.doi.org/10.1080/13880209.2017.1301493

Rankings
SCIMAGO Q1 (2017) - 0.563 - Complementary and Alternative Medicine

Keywords
alpha-glucosidase alpha-amylase Halophytes antioxidant activity oxidative stress macrophages nitric oxide

Download

Export

APA
Maria João Rodrigues, Luísa Custódio, Andreia Lopes, Marta Oliveira, Nuno R. Neng, José M. F. Nogueira, Alice Martins, Amélia P. Rauter, João Varela, Luísa Barreira, (2017). Unlocking the in vitro anti-inflammatory and antidiabetic potential of Polygonum maritimum. Pharmaceutical Biology, 55, 1348-1357. ISSN 1388-0209. eISSN . http://dx.doi.org/10.1080/13880209.2017.1301493

IEEE
Maria João Rodrigues, Luísa Custódio, Andreia Lopes, Marta Oliveira, Nuno R. Neng, José M. F. Nogueira, Alice Martins, Amélia P. Rauter, João Varela, Luísa Barreira, "Unlocking the in vitro anti-inflammatory and antidiabetic potential of Polygonum maritimum" in Pharmaceutical Biology, vol. 55, pp. 1348-1357, 2017. 10.1080/13880209.2017.1301493

BIBTEX
@article{37042, author = {Maria João Rodrigues and Luísa Custódio and Andreia Lopes and Marta Oliveira and Nuno R. Neng and José M. F. Nogueira and Alice Martins and Amélia P. Rauter and João Varela and Luísa Barreira}, title = {Unlocking the in vitro anti-inflammatory and antidiabetic potential of Polygonum maritimum}, journal = {Pharmaceutical Biology}, year = 2017, pages = {1348-1357}, volume = 55 }