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Publication details

Document type
Journal articles

Document subtype
Full paper

Title
Digestibility and bioavailability of the active components of Erica australis L. aqueous extracts and their therapeutic potential as acetylcholinesterase inhibitors

Participants in the publication
P. Dias (Author)
P.L. Falé (Author)
A. Martins (Author)
A.P. Rauter (Author)
Dep. Química e Bioquímica
 CQB
Summary
Erica australis L. (Ericaceae) is used in traditional medicine to treat many free-radical related ailments. In the present work, the stability and biological activity of the plant aqueous extracts submitted to an in vitro digestive process were investigated. Chemical stability was monitored by HPLC-DAD and LC-MS/MS, while the bioactivities were evaluated through the inhibition of acetylcholinesterase (AChE) and DPPH radical scavenging activity. Both extracts, whose main components were flavonol glycosides, inhibited AChE, showing IC50 values of 257.9 ± 6.2 µg/mL and 296.8 ± 8.8 µg/mL for the decoction and for the infusion, respectively. Significant radical scavenging activities were also revealed by both extracts, as denoted by the IC50 values for the decoction, 6.7 ± 0.1 µg/mL, and for the infusion, 10.5 ± 0.3 µg/mL. After submission to gastric and pancreatic juices, no remarkable alterations in the composition or in the bioactivities were observed, suggesting that the extracts may pass through the gastrointestinal tract, keeping their composition and therefore their biological properties. Moreover, the bioavailability of the components of both extracts, as studied in a Caco-2 cell model, showed that compounds can permeate the membrane, which is a condition to exert their biological activities. Our results add further support to the potential of E. australis for its antioxidant and neuroprotective properties.

Date of Submisson/Request
2015-04-30
Date of Acceptance
2015-07-15
Date of Publication
2015

Institution
FACULDADE DE CIÊNCIAS DA UNIVERSIDADE DE LISBOA

Where published
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE

Publication Identifiers
ISSN - 1741-427X

Volume
854373

Document Identifiers
URL - http://dx.doi.org/10.1155/2015/854373
DOI - https://doi.org/10.1155/2015/854373

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APA
P. Dias, P.L. Falé, A. Martins, A.P. Rauter, (2015). Digestibility and bioavailability of the active components of Erica australis L. aqueous extracts and their therapeutic potential as acetylcholinesterase inhibitors . EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 854373, ISSN 1741-427X. eISSN . http://dx.doi.org/10.1155/2015/854373

IEEE
P. Dias, P.L. Falé, A. Martins, A.P. Rauter, "Digestibility and bioavailability of the active components of Erica australis L. aqueous extracts and their therapeutic potential as acetylcholinesterase inhibitors " in EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 854373, 2015. 10.1155/2015/854373

BIBTEX
@article{26543, author = {P. Dias and P.L. Falé and A. Martins and A.P. Rauter}, title = {Digestibility and bioavailability of the active components of Erica australis L. aqueous extracts and their therapeutic potential as acetylcholinesterase inhibitors }, journal = {EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE}, year = 2015, volume = 854373 }