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Publication details

Document type
Patents


Title
New c-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. therapeutic applications of the synthesized agent(s) and of genista tenera ethyl acetate extracts containing some of those agents

Participants in the publication
A.P. Rauter (Author)
Dep. Química e Bioquímica
 CQB
 CQE
 A. Jesus (Author)
CQB
 A. Martins (Author)
Dep. Química e Bioquímica
 CQB
 MARE
 CQE
 C. Dias (Author)
Dep. Química e Bioquímica
 CQB
 CQE
 Rogério Ribeiro (Author)
M.- P. Macedo (Author)
J. Justino (Author)
H. Mota-Filipe (Author)
R. Pinto (Author)
B. Sepodes (Author)
M. Medeiros (Author)
J. Barbero (Author)
C. Airoldi (Author)
F. Nicotra (Author)

Summary
The present invention concerns the antidiabetic-activity of compounds type A, namely of 8-β-D-glucosylgenistein, which is not toxic to eukaryotic cells and has demonstrated to produce complete normalization of fasting hyperglycaemia, to reduce excessive postprandial glucose excursion, to increase glucose-induced insulin secretion and insulin sensitivity. An alternative synthesis for this molecular entity and its binding ability to β-amyloid oligomers is also included in the present invention, which also comprises Genista tenera ethyl acetate extract for use as antihyperglycaemic, agent i.e. for lowering blood glucose levels in mammals that are pre-diabetic or have type 2 or type 1 diabetes. The inhibitory activity of α-glucosidase by Genista tenera ethyl acetate and butanol extracts and that of glucose-6-phosphatase by these two extracts and the diethyl ether plant extract is also part of the present invention.

Date of Submisson/Request
2012-03-09
Data de Concessão
2017-10-03

Institution
UNIVERSIDADE DE LISBOA

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APA
A.P. Rauter, A. Jesus, A. Martins, C. Dias, Rogério Ribeiro, M.- P. Macedo, J. Justino, H. Mota-Filipe, R. Pinto, B. Sepodes, M. Medeiros, J. Barbero, C. Airoldi, F. Nicotra, (2017). New c-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. therapeutic applications of the synthesized agent(s) and of genista tenera ethyl acetate extracts containing some of those agents

IEEE
A.P. Rauter, A. Jesus, A. Martins, C. Dias, Rogério Ribeiro, M.- P. Macedo, J. Justino, H. Mota-Filipe, R. Pinto, B. Sepodes, M. Medeiros, J. Barbero, C. Airoldi, F. Nicotra, "New c-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. therapeutic applications of the synthesized agent(s) and of genista tenera ethyl acetate extracts containing some of those agents ", 2017

BIBTEX
@misc{26429, author = {A.P. Rauter and A. Jesus and A. Martins and C. Dias and Rogério Ribeiro and M.- P. Macedo and J. Justino and H. Mota-Filipe and R. Pinto and B. Sepodes and M. Medeiros and J. Barbero and C. Airoldi and F. Nicotra}, title = {New c-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. therapeutic applications of the synthesized agent(s) and of genista tenera ethyl acetate extracts containing some of those agents }, year = 2017 }