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Publications for laclarke (52)

2024
Novel Combined approaches to PTC mutation correction in CFTR (2024)
Henriques, Pedro Alexandre Rhodes
Clarke, Luka Alexander
Academic documents
2023
Systems Biology and the New Omics (2023)
Margarida D. Amaral
Luka A. Clarke
Carlos M. Farinha
Hugo M. Botelho
Book chapters
2023
What Can RNA-Based Therapy Do for Monogenic Diseases? (2023)
Luka A. Clarke
Margarida D. Amaral
Journal articles
2022
Optimising mRNA integrity and read-through of CFTR bearing PTC mutations (2022)
Luz, Vanessa Cristina de Carvalho
Clarke, Luka Alexander
Academic documents
2021
Integrity and Stability of PTC Bearing CFTR mRNA and Relevance to Future Modulator Therapies in Cystic Fibrosis (2021)
Luka A. Clarke et al., with 6 authors including:
Luka A. Clarke
Carlos M. Farinha
Margarida D. Amaral
Journal articles
2021
Enhanced Expression of Human Epididymis Protein 4 (HE4) Reflecting Pro-Inflammatory Status Is Regulated by CFTR in Cystic Fibrosis Bronchial Epithelial Cells (2021)
Zsolt Bene et al., with 11 authors including:
Luka A. Clarke
Margarida D. Amaral
Journal articles
2020
Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A>G (2020)
Iris A.L. Silva et al., with 14 authors including:
Iris A.L. Silva
Luka A. Clarke
Violeta Railean
Hugo M. Botelho
Carlos M. Farinha
Margarida D. Amaral
Journal articles
2020
Mutant CFTR Drives TWIST1 mediated epithelial–mesenchymal transition (2020)
Margarida C. Quaresma et al., with 9 authors including:
Margarida C. Quaresma
Ines Pankonien
Luka A. Clarke
Iris A. L. Silva
Violeta Railean
Margarida D. Amaral
Journal articles
2020
KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway (2020)
Luis Sousa et al., with 6 authors including:
Ines Pankonien
Luka A Clarke
Iris Silva
Margarida D Amaral
Journal articles
2019
TMEM16A chloride channel does not drive mucus production (2019)
Filipa B Simões et al., with 8 authors including:
Margarida C Quaresma
Luka A Clarke
Iris AL Silva
Ines Pankonien
Violeta Railean
Arthur Kmit
Margarida D Amaral
Journal articles
2019
The effect of premature termination codon mutations on CFTR mRNA abundance in human nasal epithelium and intestinal organoids: a basis for read?through therapies in cystic fibrosis (2019)
Luka A. Clarke et al., with 13 authors including:
Luka A. Clarke
Nikhil T. Awatade
Iris A. Silva
Margarida D. Amaral
Journal articles
2019
BO-LSTM: classifying relations via long short-term memory networks along biomedical ontologies (2019)
Andre Lamurias
Diana Sousa
Luka A. Clarke
Francisco M. Couto
Journal articles
2019
Regulation of glucose uptake in mammalian cells by protein phosphorylation networks (2019)
Henriques, Andreia Filipa Almeida
Jordan, Peter
Clarke, Luka
Academic documents
2019
Development of a text mining approach to disease network discovery (2019)
Lamúrias, André Francisco Martins
Couto, Francisco Jose Moreira
Clarke, Luka Alexander
Academic documents
2019
Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks (2019)
Loureiro, Cláudia Almeida
Jordan, Peter
Clarke, Luka
Academic documents
2017
Generating a Tolerogenic Cell Therapy Knowledge Graph from Literature (2017)
Andre Lamurias
João D. Ferreira
Luka A. Clarke
Francisco M. Couto
Journal articles
2017
Extracting microRNA-gene relations from biomedical literature using distant supervision (2017)
Andre Lamurias
Luka A. Clarke
Francisco M. Couto
Journal articles
2016
Human Epididymis Protein 4: A Novel Serum Inflammatory Biomarker in Cystic Fibrosis (2016)
Béla Nagy et al., with 20 authors including:
Luka A. Clarke
Margarida D. Amaral
Journal articles
2016
Functional coherence metrics in protein families (2016)
Hugo P. Bastos
Lisete Sousa
Luka A. Clarke
Francisco M. Couto
Journal articles
2016
Comparative ex vivo, in vitro and in silico analyses of a CFTR splicing mutation: Importance of functional studies to establish disease liability of mutations (2016)
Anabela S. Ramalho et al., with 7 authors including:
Luka A. Clarke
Margarida D. Amaral
Journal articles
2016
Correction of a Cystic Fibrosis Splicing Mutation by Antisense Oligonucleotides (2016)
Susana Igreja
Luka A. Clarke
Hugo M. Botelho
Luís Marques
Margarida D. Amaral
Journal articles
2015
Transcriptome meta-analysis reveals common differential and global gene expression profiles in cystic fibrosis and other respiratory disorders and identifies CFTR regulators (2015)
Luka A. Clarke
Hugo M. Botelho
Lisete Sousa
Andre O. Falcao
Margarida D. Amaral
Journal articles
2015
GRYFUN: A web application for GO term annotation visualization and analysis in protein sets (2015)
Hugo Bastos
L. Sousa
L. Clarke
Francisco Couto
Journal articles
2015
Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis (2015)
Nikhil T. Awatade et al., with 9 authors including:
Carlos M. Farinha
Luka A. Clarke
Margarida D. Amaral
Journal articles
2015
Functional coherence and annotation agreement metrics for enzyme families (2015)
Hugo Bastos
Francisco José Moreira Couto
Luka Alexander Clarke
Academic documents
2013
High-Content siRNA Screen Reveals Global ENaC Regulators and Potential Cystic Fibrosis Therapy Targets (2013)
Joana Almaça et al., with 15 authors including:
Inna Uliyakina
Luka A. Clarke
Margarida D. Amaral
Journal articles
2013
Annotation extension through protein family annotation coherence metrics (2013)
Hugo P. Bastos
Luka A. Clarke
Francisco M. Couto
Journal articles
2013
Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies (2013)
Luka A Clarke
Lisete Sousa
Celeste Barreto
Margarida D Amaral
Journal articles
2012
Role of ubiquitin ligases in pathophysiology of cystic fibrosis (2012)
Canato, Sara Inês de Ascensão Tavares
Clarke, Luka A.
Telhada, Maria Margarida Blasques
Academic documents
2011
F508del-CFTR increases intracellular Ca2+ signaling that causes enhanced calcium-dependent Cl- conductance in cystic fibrosis (2011)
Joana Raquel Martins et al., with 10 authors including:
Luka Alexander Clarke
Margarida D. Amaral
Journal articles
2011
Microarray mRNA Expression Profiling to Study Cystic Fibrosis (2011)
Shyam Ramachandran
Luka A. Clarke
Todd E. Scheetz
Margarida D. Amaral
Paul B. McCray
Book chapters
2011
Quantification of CFTR Transcripts (2011)
Anabela S. Ramalho
Luka A. Clarke
Margarida D. Amaral
Book chapters
2005
Detection of cystic fibrosis related DNA targets using AC field focusing of magnetic labels and spin-valve sensors (2005)
H.A. Ferreira et al., with 6 authors including:
H.A. Ferreira
L.A. Clarke
M.D. Amaral
Journal articles
2005
Rapid DNA hybridization based on ac field focusing of magnetically labeled target DNA (2005)
H. A. Ferreira et al., with 6 authors including:
H. A. Ferreira
L. A. Clarke
M. D. Amaral
Journal articles
2005
Magnetic field-assisted DNA hybridisation and simultaneous detection using micron-sized spin-valve sensors and magnetic nanoparticles (2005)
D.L. Graham et al., with 6 authors including:
H.A. Ferreira
L.A. Clarke
M.D. Amaral
Journal articles
2005
The replication timing of CFTR and adjacent genes (2005)
Andreas Englmann et al., with 6 authors including:
Luka A. Clarke
Margarida D. Amaral
Journal articles
2005
Magnetic biosensors for genetic screening of cystic fibrosis (2005)
L. Lagae et al., with 12 authors including:
H.A. Ferreira
L.A. Clarke
M.D. Amaral
Journal articles
2004
Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei (2004)
Daniele Zink et al., with 12 authors including:
Margarida D. Amaral
Luka A. Clarke
Journal articles
2004
Quantitative methods for the analysis of CFTR transcripts/splicing variants (2004)
Margarida D. Amaral et al., with 19 authors including:
Margarida D. Amaral
Luka A. Clarke
Journal articles
2004
Methods for RNA extraction, cDNA preparation and analysis of CFTR transcripts (2004)
Anabela S. Ramalho et al., with 11 authors including:
Carlos M. Farinha
Luka A. Clarke
Margarida D. Amaral
Journal articles
2004
Microarray analysis in cystic fibrosis (2004)
Paul Galvin
Luka A. Clarke
Sara Harvey
Margarida D. Amaral
Journal articles
2004
Magnetoresistive DNA chips (2004)
P.P. Freitas et al., with 8 authors including:
H.A. Ferreira
L.A. Clarke
M.D. Amaral
Book chapters
2003
Magnetoresistive biochips (2003)
P. P. Freitas et al., with 8 authors including:
H. Ferreira
L. Clarke
M. Amaral
Journal articles
2001
PCR amplification introduces errors into mononucleotide and dinucleotide repeat sequences (2001)
L A Clarke
C S Rebelo
J Gonçalves
M G Boavida
P Jordan
Journal articles
2000
Pathological exon skipping in an HNPCC proband with MLH1 splice acceptor site mutation (2000)
L A Clarke et al., with 7 authors including:
L A Clarke
Journal articles
2000
Cell type specificity in alternative splicing of the human mismatch repair gene hMSH2 (2000)
Luka A Clarke
Peter Jordan
Maria Guida Boavida
Journal articles
1998
Alternative splicing of the prolactin receptor gene generates a 1.7 kb RNA transcript that is linked to prolactin function in the red deer testis (1998)
HN Jabbour et al., with 6 authors including:
LA Clarke
Journal articles
1998
Is prolactin a gonadotrophic hormone in red deer (Cervus elaphus)? Pattern of expression of the prolactin receptor gene in the testis and epididymis (1998)
HN Jabbour
LA Clarke
AS McNeilly
M Edery
PA Kelly
Journal articles
1997
Expression and Localization of Prolactin Receptor Messenger Ribonucleic Acid in Red Deer Ovary During the Estrous Cycle and Pregnancy1 (1997)
Luka A. Clarke
D. Claire Wathes
Henry N. Jabbour
Journal articles
1996
Cloning, sequencing and functional analysis of a truncated cDNA encoding red deer prolactin receptor: an alternative tyrosine residue mediates ?-casein promoter activation (1996)
H.N. Jabbour et al., with 6 authors including:
L.A. Clarke
Journal articles
1995
Expression of the prolactin receptor gene during the breeding and non-breeding seasons in red deer (Cervus elaphus): evidence for the expression of two forms in the testis (1995)
L A Clarke et al., with 7 authors including:
L A Clarke
Journal articles
1992
The function of bill-wiping (1992)
Innes Cuthill
Mark Witter
Luka Clarke
Journal articles